Summary of Study ST000590
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000431. The data can be accessed directly via it's Project DOI: 10.21228/M8BK5R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST000590 |
| Study Title | Human Plasma Metabolomics in Age-related Macular Degeneration (AMD) Using Nuclear Magnetic Resonance Spectroscopy |
| Study Type | Observational, cross-sectional, multi-site study, NMR metabolomics |
| Study Summary | Multi-site, cross-sectional study, including subjects with Age-related Macular Degeneration (early, intermediate and late disease) and a control group of subjects without any macular diseases. Plasma metabolomic profiles were assessed using Nuclear Magnetic Resonance Spectroscopy (NMR). Multivariate statistics were performed to compare metabolomic profiles of AMD patients vs controls. |
| Institute | University of Aveiro |
| Department | Department of Chemistry and CICECO_Aveiro Institute of Materials |
| Laboratory | University of Aveiro |
| Last Name | Gil |
| First Name | Ana |
| Address | Campus de Santiago, Aveiro, Aveiro, 3810-193, Portugal |
| agil@ua.pt | |
| Phone | +351234370707 |
| Submit Date | 2017-02-20 |
| Num Groups | 4 |
| Total Subjects | 396 |
| Num Males | 143 |
| Num Females | 253 |
| Analysis Type Detail | NMR |
| Release Date | 2017-07-10 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO000607 |
| Collection Summary: | For all participants, fasting blood samples were collected into sodium-heparin tubes, and centrifuged within 30 min (1500 rpm, 10 min, 20ºC). Plasma aliquots of 1.5 mL (MEE) and 5 mL (FMUC/AIBILI) were transferred into sterile cryovials and stored at -80ºC. Plasma samples from MEE were shipped to Portugal for metabolomic profiling in dry ice (through TNT Express, USA, INC). Samples arrived frozen in less than 48 hours and were immediately stored at -80ºC until NMR analysis. |
| Sample Type: | Blood plasma |
| Collection Method: | For all participants, fasting blood samples were collected into sodium-heparin tubes, and centrifuged within 30 min (1500 rpm, 10 min, 20ºC). Plasma aliquots of 1.5 mL (MEE) and 5 mL (FMUC/AIBILI) were transferred into sterile cryovials and stored at -80ºC. Plasma samples from MEE were shipped to Portugal for metabolomic profiling in dry ice (through TNT Express, USA, INC). Samples arrived frozen in less than 48 hours and were immediately stored at -80ºC until NMR analysis. |
| Collection Location: | Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, US; Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal. |
| Collection Frequency: | one collection |
| Volumeoramount Collected: | 9 tp 10 mL |
| Storage Conditions: | Plasma aliquots were stored at -80ºC. Plasma samples from MEE were shipped to Portugal for metabolomic profiling in dry ice (through TNT Express, USA, INC). Samples arrived frozen in less than 48 hours and were immediately stored at -80ºC until NMR analysis. |
| Collection Vials: | sodium-heparin tubes |
| Storage Vials: | sterile cryovials |
| Collection Tube Temp: | room temperature |
| Additives: | No |
| Blood Serum Or Plasma: | Yes, blood samples were collected, which were then centrifuged to obtain plasma |
