Summary of Study ST002114

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001192. The data can be accessed directly via it's Project DOI: 10.21228/M8MX3X This work is supported by NIH grant, U2C- DK119886.

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Study IDST002114
Study TitleInvolvement of Mieap in Cardiolipin metabolism (part I-revised)
Study SummaryCardiolipin (CL) alterations cause mitochondrial dysfunction. Mieap is involved in mitochondrial quality control (MQC). To investigate whether Mieap functions in MQC via regulation of CL metabolism, quantitative assessment of total CL and comparison of CL species conducted with A549 (Ad-Mieap infected vs. non-infected) and LS174T cells (LS174T-cont vs. Mieap-KD). The A549 cells were harvested 24 hr after infection with Ad-Mieap and were compared with non-infected cells by mass spectrometric analysis. The LS174T-cont and Mieap-KD cells incubated under a normal condition were harvested and subjected to mass spectrometric analysis.
Institute
National Cancer Center Japan Research Institute
Last NameIkari
First NameNaoki
Address5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Emailnikari@ncc.go.jp
Phone+81335422511
Submit Date2022-02-13
Raw Data AvailableYes
Raw Data File Type(s)cdf, raw(Thermo)
Analysis Type DetailLC-MS
Release Date2022-03-21
Release Version2
Release CommentsReplacement for ST001893 (datatrack 2779)
Naoki Ikari Naoki Ikari
https://dx.doi.org/10.21228/M8MX3X
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Cultured cells; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Genotype/Treatment
SA202952A549 Ad-Mieap 4Ad-Mieap infection
SA202953A549 Ad-Mieap 1Ad-Mieap infection
SA202954A549 Ad-Mieap 3Ad-Mieap infection
SA202955A549 Ad-Mieap 2Ad-Mieap infection
SA202956LS174T Control 3Control
SA202957LS174T Control 4Control
SA202958LS174T Control 6Control
SA202959LS174T Control 5Control
SA202960LS174T Control 2Control
SA202961LS174T Control 1Control
SA202962LS174T Mieap-KD 5Mieap-knockdown
SA202963LS174T Mieap-KD 6Mieap-knockdown
SA202964LS174T Mieap-KD 1Mieap-knockdown
SA202965LS174T Mieap-KD 4Mieap-knockdown
SA202966LS174T Mieap-KD 2Mieap-knockdown
SA202967LS174T Mieap-KD 3Mieap-knockdown
SA202968A549 Non-infection 1Non-infection
SA202969A549 Non-infection 3Non-infection
SA202970A549 Non-infection 2Non-infection
SA202971A549 Non-infection 4Non-infection
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