Summary of Study ST003042
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001893. The data can be accessed directly via it's Project DOI: 10.21228/M81F0P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003042 |
| Study Title | The metabolomic resetting effect of DY131 in cisplatin-induced AKI |
| Study Type | MS |
| Study Summary | LC-MS/MS analyses were performed using renal tissues from cisplatin-induced AKI mice with or without DY131 treatment. The data revealed that DY131 alleviated cisplatin-induced mitochondrial dysfunction and energy metabolism disorder, as well as multiple metabolic disorders. |
| Institute | Children's Hospital of Nanjing Medical University |
| Department | Department of Nephrology, State Key Laboratory of Reproductive Medicine |
| Laboratory | Nanjing Key Lab of Pediatrics, Jiangsu Key Laboratory of Pediatrics |
| Last Name | Lu |
| First Name | Lingling |
| Address | Guangzhou Road 72, Nanjing, Jiangsu, 210000, China |
| lulingling89tara@163.com | |
| Phone | 0086-25-8311-7435 |
| Submit Date | 2023-12-21 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzXML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-02-08 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN004990 | AN004991 |
|---|---|---|
| Analysis type | MS | MS |
| Chromatography type | HILIC | HILIC |
| Chromatography system | Thermo Fisher Scientific | Thermo Fisher Scientific |
| Column | Waters ACQUITY UPLC BEH Amide (100 x 2.1mm,1.7um) | Waters ACQUITY UPLC BEH Amide (100 x 2.1mm,1.7um) |
| MS Type | ESI | ESI |
| MS instrument type | Orbitrap | Orbitrap |
| MS instrument name | Thermo Q Exactive HF-X Orbitrap | Thermo Q Exactive HF-X Orbitrap |
| Ion Mode | POSITIVE | NEGATIVE |
| Units | Peak area | Peak area |
MS:
| MS ID: | MS004730 |
| Analysis ID: | AN004990 |
| Instrument Name: | Thermo Q Exactive HF-X Orbitrap |
| Instrument Type: | Orbitrap |
| MS Type: | ESI |
| MS Comments: | sheath gas flow rate as 30 Arb, Aux gas flow rate as 25 Arb, capillary temperature 350 ℃, full MS resolution as 60000, MS/MS resolution as 7500, collision energy as 10/30/60 in NCE mode, spray Voltage as 3.6 kV (positive). Metabolites were quantified by relative quantification and expressed by peak area. |
| Ion Mode: | POSITIVE |
| Analysis Protocol File: | DY131_MS.txt |
| MS ID: | MS004731 |
| Analysis ID: | AN004991 |
| Instrument Name: | Thermo Q Exactive HF-X Orbitrap |
| Instrument Type: | Orbitrap |
| MS Type: | ESI |
| MS Comments: | sheath gas flow rate as 30 Arb, Aux gas flow rate as 25 Arb, capillary temperature 350 ℃, full MS resolution as 60000, MS/MS resolution as 7500, collision energy as 10/30/60 in NCE mode, spray Voltage as -3.2 kV (negative). Metabolites were quantified by relative quantification and expressed by peak area. |
| Ion Mode: | NEGATIVE |
| Analysis Protocol File: | DY131_MS.txt |
