Summary of Study ST003042
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001893. The data can be accessed directly via it's Project DOI: 10.21228/M81F0P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003042 |
| Study Title | The metabolomic resetting effect of DY131 in cisplatin-induced AKI |
| Study Type | MS |
| Study Summary | LC-MS/MS analyses were performed using renal tissues from cisplatin-induced AKI mice with or without DY131 treatment. The data revealed that DY131 alleviated cisplatin-induced mitochondrial dysfunction and energy metabolism disorder, as well as multiple metabolic disorders. |
| Institute | Children's Hospital of Nanjing Medical University |
| Department | Department of Nephrology, State Key Laboratory of Reproductive Medicine |
| Laboratory | Nanjing Key Lab of Pediatrics, Jiangsu Key Laboratory of Pediatrics |
| Last Name | Lu |
| First Name | Lingling |
| Address | Guangzhou Road 72, Nanjing, Jiangsu, 210000, China |
| lulingling89tara@163.com | |
| Phone | 0086-25-8311-7435 |
| Submit Date | 2023-12-21 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzXML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-02-08 |
| Release Version | 1 |
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Treatment:
| Treatment ID: | TR003166 |
| Treatment Summary: | Wild type C57BL/6J mice were maintained under standard environmental conditions. A single injection of cisplatin (25 mg/kg, i.p.) was used to induce AKI. DY131 was dissolved in DMSO and further diluted with 5% Tween-80. To assess the effect of DY131, the mice were injected with DY131 (5 mg/kg, i.p.) or vehicle one hour before cisplatin injection, repeated every 24 hours. The mice were euthanized 72 hours after cisplatin injection. |
| Treatment Compound: | cisplatin or saline, DY131 or vehicle |
| Treatment Route: | intraperitoneal injection |
| Treatment Dose: | cisplatin at 25 mg/kg, once. DY131 at 5 mg/kg, once a day for 3 days |
| Treatment Dosevolume: | Animal Vet Treatments: Animal Anesthesia: Animal Acclimation Duration: Animal Fasting: Animal Endpoint Euthanasia: Animal Endpoint Tissue Coll. List: Animal Endpoint Tissue Proc. Method: Animal Endpoint Clinical Signs: |
| Treatment Vehicle: | cisplatin dissolved in saline, DY131 dissolved in DMSO and further diluted with 5% Tween-80 |
