Summary of Study ST003042
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001893. The data can be accessed directly via it's Project DOI: 10.21228/M81F0P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST003042 |
Study Title | The metabolomic resetting effect of DY131 in cisplatin-induced AKI |
Study Type | MS |
Study Summary | LC-MS/MS analyses were performed using renal tissues from cisplatin-induced AKI mice with or without DY131 treatment. The data revealed that DY131 alleviated cisplatin-induced mitochondrial dysfunction and energy metabolism disorder, as well as multiple metabolic disorders. |
Institute | Children's Hospital of Nanjing Medical University |
Department | Department of Nephrology, State Key Laboratory of Reproductive Medicine |
Laboratory | Nanjing Key Lab of Pediatrics, Jiangsu Key Laboratory of Pediatrics |
Last Name | Lu |
First Name | Lingling |
Address | Guangzhou Road 72, Nanjing, Jiangsu, 210000, China |
lulingling89tara@163.com | |
Phone | 0086-25-8311-7435 |
Submit Date | 2023-12-21 |
Raw Data Available | Yes |
Raw Data File Type(s) | mzXML |
Analysis Type Detail | LC-MS |
Release Date | 2024-02-08 |
Release Version | 1 |
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Sample Preparation:
Sampleprep ID: | SP003163 |
Sampleprep Summary: | 25 mg of sample was weighted to an EP tube, and 500 μL extract solution (acetonitrile: methanol: water = 2: 2: 1, with isotopically-labelled internal standard mixture) was added. After 30 s vortex, the samples were homogenized at 35 Hz for 4 min and sonicated for 5 min in ice-water bath. The homogenization and sonication cycle was repeated for 3 times. Then the samples were incubated for 1 h at -40 ℃ and centrifuged at 12000 rpm for 15 min at 4 ℃. The resulting supernatant was transferred to a fresh glass vial for analysis. |