Summary of Study ST001021
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000683. The data can be accessed directly via it's Project DOI: 10.21228/M8D11B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001021 |
| Study Title | Characterization of metabolomics profile changes during development of post-traumatic epilepsy in Rat Cerebrospinal Fluid (part-II) |
| Study Summary | Characterize the metabolomics profile changes during progression of the transition from traumatic brain injury (TBI) to post-traumatic epilepsy (PTE). To do so, three experiments will be performed. PTE animal model will be developed using ferrous chloride injections. Metabolomics profile changes will be obtained before TBI, after TBI, and after PTE development These temporal changes in metabolomics profile during the course of PTE development will be collected. We will also collect cerebrospinal fluid (CSF) at each time point. In addition, we will collect the brain tissue from the center of injury, around the injury, and from the non-injured area for mass spectrometry. In this study, Rat CSF is analyzed at end of study. |
| Institute | Mayo Clinic |
| Last Name | Su-youne |
| First Name | Chang |
| Address | 200 1st Street SW Rochester, MN 55905, USA |
| Chang.SuYoune@mayo.edu | |
| Phone | 1-507-293-0511 |
| Submit Date | 2018-07-17 |
| Analysis Type Detail | LC-MS |
| Release Date | 2020-07-15 |
| Release Version | 1 |
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Project:
| Project ID: | PR000683 |
| Project DOI: | doi: 10.21228/M8D11B |
| Project Title: | Mayo Pilot and Feasibility: Characterization of metabolomics profile changes during development of post-traumatic epilepsy |
| Project Summary: | According to the report from the Centers for Disease Control and Prevention in 2014, traumatic brain injury (TBI) accounts for 30% of all injury-related deaths in the U.S. Developing epilepsy after severe head injury is as high as 40%-50% in some settings. Importantly, many TBI victims develop epilepsy months or years following the initial injury. However, it has not been fully identified how to predict who will develop epilepsy and/or the underlying mechanism of post traumatic epilesy (PTE) development. The main goal of this proposal is to identify the metabolomics biomarker of TBI-induced epilepsy and to investigate the underlying mechanism of the transition from TBI to PTE. To do so, we will develop PTE using two TBI animal models: ferrous chloride injection model and cortical undercut model. Once the brain damage is made, electroencephalogram (EEG) and video monitoring will be performed to determine the onset point of epilepsy. Then, metabolomics profile changes will be analyzed and compared before and after PTE development. |
| Institute: | Mayo Clinic |
| Last Name: | Su-youne |
| First Name: | Chang |
| Address: | 200 1st Street SW Rochester, MN 55905, USA |
| Email: | Chang.SuYoune@mayo.edu |
| Phone: | 1-507-293-0511 |
