Summary of Study ST001508
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001017. The data can be accessed directly via it's Project DOI: 10.21228/M87M4S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001508 |
| Study Title | Liver metabolomics in old liver-specific SIRT6 overexpressing mice |
| Study Summary | Our previous data had suggested that gluconeogenesis capacity from the precursors lactate and glycerol declines in old C57BL/6 mice. This decline was rescued by whole body SIRT6 overexpression, but not in liver-specific SIRT6 overexpression. Here we preformed liver metabolomics in old liver-specific SIRT6 overexpression and control mice. |
| Institute | Bar Ilan University |
| Department | The Mina & Everard Goodman Faculty of Life Sciences |
| Laboratory | Laboratory of Prof. Haim Cohen |
| Last Name | Cohen |
| First Name | Chaim |
| Address | Bar Ilan University, Ramat Gan, Israel, 5290002 |
| Haim.Cohen@biu.ac.il | |
| Phone | +97235318383 |
| Submit Date | 2020-10-07 |
| Num Groups | 4 |
| Total Subjects | 20 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2021-03-11 |
| Release Version | 1 |
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Project:
| Project ID: | PR001017 |
| Project DOI: | doi: 10.21228/M87M4S |
| Project Title: | Hepatic [U-13C]Lactate tracing and metabolomics in young and old WT and SIRT6 overexpressing mice |
| Project Type: | MS analysis |
| Project Summary: | Our previous data had suggested that gluconeogenesis capacity from the precursors lactate and glycerol declines in old C57BL/6 mice. This decline was rescued by whole body SIRT6 overexpression. Since the liver is the main gluconeogenic organ, we performed here liver metabolomics in young (6 months) versus old (20-24 months) WT and SIRT6-transgenic mice. We used liver tissues of 6h morning-fasted mice, either in naïve state or 15 minutes after intraperitoneal injection of [U-13C]Lactate. |
| Institute: | Bar Ilan University |
| Department: | The Mina & Everard Goodman Faculty of Life Sciences |
| Laboratory: | Laboratory of Prof. Haim Cohen |
| Last Name: | Cohen |
| First Name: | Chaim |
| Address: | Ramat Gan, Ramat Gan, Israel, 5290002, Israel |
| Email: | Haim.Cohen@biu.ac.il |
| Phone: | +97235318383 |
| Funding Source: | Israel Science Foundation (621/13 and 777/16), I-Core foundation (1775/12) and (41/11) and Laura and Isaac Perlmutter Foundation |
| Contributors: | Asael Roichman, Ifat Abramovich, Eyal Gottlieb, Haim Yosef Cohen |
