Summary of Study ST001758
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001126. The data can be accessed directly via it's Project DOI: 10.21228/M8569X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001758 |
| Study Title | Metabolomics of mouse cerebral cortical brain tissues comparing GF and CONV-R mice |
| Study Type | untargeted metabolomics |
| Study Summary | Using high coverage metabolomics, we profiled feces, blood sera and cerebral cortical brain tissues of germ-free C57BL/6 mice and their age-matched conventionally raised counterparts. Results revealed for all three sample matrices metabolomic signatures owing to microbiota, yielding hundreds of identified metabolites including 533 altered for feces, 231 for sera and 58 for brain tissues with numerous significantly enriched pathways involving aromatic amino acids and neurotransmitters. |
| Institute | University of North Carolina at Chapel Hill |
| Department | Department of Environmental Sciences and Engineering |
| Last Name | Lai |
| First Name | Yunjia |
| Address | 1104 MHRC, 135 Dauer Dr., Chapel Hill, NC 27599 |
| yunjia.lai@outlook.com | |
| Phone | 9194805489 |
| Submit Date | 2021-04-28 |
| Num Groups | 2 |
| Total Subjects | 24 |
| Num Males | 12 |
| Num Females | 12 |
| Publications | Nature Communications |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzXML |
| Analysis Type Detail | LC-MS |
| Release Date | 2021-07-26 |
| Release Version | 1 |
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Project:
| Project ID: | PR001126 |
| Project DOI: | doi: 10.21228/M8569X |
| Project Title: | High-coverage metabolomics annotation uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication |
| Project Type: | untargeted metabolomics |
| Project Summary: | The mammalian gut harbors a complex and dynamic microbial ecosystem: the microbiota. While emerging studies support that microbiota regulates brain function with a few molecular cues suggested, the overall biochemical landscape of the “microbiota-gut-brain axis” remains largely unclear. Using high coverage metabolomics, we profiled feces, blood sera and cerebral cortical brain tissues of germ-free C57BL/6 mice and their age-matched conventionally raised counterparts. Results revealed for all three sample matrices metabolomic signatures owing to microbiota, yielding hundreds of identified metabolites including 533 altered for feces, 231 for sera and 58 for brain tissues with numerous significantly enriched pathways involving aromatic amino acids and neurotransmitters. Multicompartmental comparative analyses singled out microbiota-derived metabolites potentially implicated in interorgan transport and the gut-brain axis, exemplified by indoxyl sulfate and trimethylamine-N-oxide. Gender-specific characteristics of these landscapes were discussed. Our findings may be valuable for future research probing microbial influences on host metabolism and gut-brain communication. |
| Institute: | University of North Carolina at Chapel Hill |
| Department: | Department of Environmental Sciences and Engineering |
| Last Name: | Lai |
| First Name: | Yunjia |
| Address: | 1104 MHRC, 135 Dauer Dr., Chapel Hill, NC, 27599, USA |
| Email: | yunjia.lai@outlook.com |
| Phone: | 9194805489 |
| Funding Source: | NIEHS |
