Summary of Study ST002189
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001395. The data can be accessed directly via it's Project DOI: 10.21228/M8DB02 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST002189 |
| Study Title | Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice (Aqueous) |
| Study Type | Study of the skeletal muscle metabolome in mice with iliac arteriovenous fistula via 1H NMR |
| Study Summary | In the present study, we hypothesize that the creation of an iliac AVF would result in significant alterations to the limb muscle metabolome. Recently, our group developed a new murine model to address the pathophysiology of access-related hand dysfunction (ARHD) in mice, where AVF creation is performed in the iliac artery/vein. Because of the anatomical location of the AVF creation, this model produces clinically relevant changes in the mouse hindlimb including hemodynamic alterations, muscle weakness, and mitochondrial function impairment. |
| Institute | University of Florida |
| Department | Applied Physiology and Kinesiology |
| Laboratory | Rm 42 and Rm 43 |
| Last Name | Ryan |
| First Name | Terence |
| Address | 1864 Stadium Rd, FLG 114, Gainesville, FL, 32611, USA |
| ryant@ufl.edu | |
| Phone | 352-294-1700 |
| Submit Date | 2022-02-17 |
| Num Groups | 4 |
| Total Subjects | 34 |
| Num Males | All |
| Study Comments | Metabolomic study via NMR |
| Publications | Frontiers |
| Raw Data Available | Yes |
| Raw Data File Type(s) | fid |
| Analysis Type Detail | NMR |
| Release Date | 2022-08-01 |
| Release Version | 1 |
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Project:
| Project ID: | PR001395 |
| Project DOI: | doi: 10.21228/M8DB02 |
| Project Title: | Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice |
| Project Type: | Study of the skeletal muscle metabolome in mice with iliac arteriovenous fistula via 1H NMR |
| Project Summary: | In the present study, we hypothesize that the creation of an iliac AVF would result in significant alterations to the limb muscle metabolome. Recently, our group developed a new murine model to address the pathophysiology of access-related hand dysfunction (ARHD) in mice, where AVF creation is performed in the iliac artery/vein. Because of the anatomical location of the AVF creation, this model produces clinically relevant changes in the mouse hindlimb including hemodynamic alterations, muscle weakness, and mitochondrial function impairment. |
| Institute: | University of Florida |
| Department: | Applied Physiology and Kinesiology |
| Laboratory: | Rm 42 and Rm 43 |
| Last Name: | Ryan |
| First Name: | Terence |
| Address: | 1864 Stadium Rd, FLG 114, Gainesville, FL, 32611, USA |
| Email: | ryant@ufl.edu |
| Phone: | 352-294-1700 |
| Funding Source: | National Institutes of Health (NIH) grant R01HL148597 (STS). Additional salary support was provided by NIH grants R01DK119274 (SAB) and R01HL149704 (TER), and a postdoctoral fellowship (POST903198) from the American Heart Association (KK). |
| Project Comments: | Metabolomic study via NMR |
| Publications: | Frontiers |
| Contributors: | Ram B. Khattri, Kyoungrae Kim, Erik M. Anderson, Brian Fazzone, Kenneth C Harland, Qiongyao Hu, Victoria R. Palzkill, Tomas A. Cort, Kerri A. O’Malle, Scott A. Berceli, Terence E. Ryan, Salvatore T. Scali |
