Summary of Study ST003031
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001884. The data can be accessed directly via it's Project DOI: 10.21228/M8672X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003031 |
| Study Title | Early time-restricted eating improves markers of cardiometabolic health but has no impact on nutrient absorption in healthy adults |
| Study Type | Randomized Controlled Trial |
| Study Summary | Metabolomic analysis performed on 88 human plasma samples collected from 16 participants that received 2 treatments with 3 time points each. Samples were analyzed by UPLC-MS using a Waters Acquity UPLC and detected on a 4000 QTrap by multiple reaction monitoring (MRM) with negative mode electrospray ionization. |
| Institute | California Polytechnic State University, San Luis Obispo |
| Last Name | La Frano |
| First Name | Michael |
| Address | Cal Poly State University 1 Grand Avenue San Luis Obispo, CA 93407 |
| mlafrano@calpoly.edu | |
| Phone | (805) 756-6233 |
| Submit Date | 2023-12-15 |
| Num Groups | 2 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-01-23 |
| Release Version | 1 |
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Project:
| Project ID: | PR001884 |
| Project DOI: | doi: 10.21228/M8672X |
| Project Title: | Early time-restricted eating improves markers of cardiometabolic health but has no impact on nutrient absorption in healthy adults |
| Project Type: | Randomized Controlled Trial |
| Project Summary: | Early time-restricted eating (eTRE) improves aspects of cardiometabolic health. Although the circadian system appears to regulate nutrient absorption, little is known about the effects of eTRE on intestinal absorption. In this randomized crossover trial, 16 healthy adults follow a controlled, weight-maintenance diet for 9 days consuming all calories between 0800 and 1400 (eTRE schedule) or 0800 and 2000 (control schedule). We measure the energy content of the diet, stool, and urine with bomb calorimetry and calculate intestinal energy absorption. The eTRE schedule is more effective than the control eating schedule for improving markers of cardiometabolic health, including 24-h mean glucose concentrations and glycemic variability, assessed as the mean amplitude of glycemic excursions. However, eTRE has no effect on intestinal energy and macronutrient absorption, gastrointestinal transit time, colonic hydrogen gas production, or stool microbial composition, suggesting eTRE does not impact gastrointestinal function. |
| Institute: | Pennington Biomedical Research Center |
| Department: | Clinical Sciences |
| Last Name: | Berryman |
| First Name: | Claire |
| Address: | 6400 Perkins Road, Baton Rouge, LA 70808 |
| Email: | claire.berryman@pbrc.edu |
| Phone: | (225) 763-3010 |
