Summary of Study ST000442

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000341. The data can be accessed directly via it's Project DOI: 10.21228/M8989V This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study IDST000442
Study TitleMetabolomics Analysis of Triple Negative Breast Cancer (BCa) Cell Lines
Study TypeMetabolomics comparison of different breast cancer cell lines
Study SummaryWe used untargeted metabolomic profiling to distinguish this form of BCa from estrogen receptor positive (ER+) subtypes (+/- HER2/neu) and determine that may explain why a commonly used chemotherapeutic, paclitaxel, is generally ineffective at eliciting long-term cytotoxic and/or cytostatic responses in cell line models of TNBC. This metabolomics study used broad spectrum 1H NMR to compare Luminal A (BT474, MCF-7) and triple-negative (MDA-MB-231, MDA-MB-468) BCa cell lines, to determine differences in the two subtypes as well as distinguish therapeutic treatment responses for identifying new targets for drug discovery.
Institute
University of North Carolina
DepartmentDiscovery Sciences
LaboratorySumner Lab
Last NameSumner
First NameSusan
AddressEastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081
Emailsusan_sumner @unc.edu
Phone704-250-5066
Submit Date2016-08-02
Num Groups4
Total Subjects24
Study Comments4 breast cancer cell lines, treated with paclitaxel compared to controls (3 replicates/line/condition)
PublicationsJ. Proteome Res., Article ASAP, DOI: 10.1021/acs.jproteome.6b00430
Raw Data AvailableYes
Raw Data File Type(s)1r
Analysis Type DetailNMR
Release Date2016-12-22
Release Version1
Susan Sumner Susan Sumner
https://dx.doi.org/10.21228/M8989V
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Subject:

Subject ID:SU000463
Subject Type:Cells
Subject Species:Homo sapiens
Taxonomy ID:9606
Cell Biosource Or Supplier:American Type Culture Collection
Cell Strain Details:Breast Cancer Cell lines (BT474, MCF-7, MDA-MB-231, MDA-MB-468)
Cell Primary Immortalized:Immortalized
Species Group:Human
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