Summary of Study ST000166

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000144. The data can be accessed directly via it's Project DOI: 10.21228/M8C01P This work is supported by NIH grant, U2C- DK119886.


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Study IDST000166
Study TitleCardiac Resynchronization Therapy Induces Adaptive Metabolic Transitions in the Metabolomic Profile of Heart Failure
Study Typeintervention
Study SummaryThis prospective study consisted of 24 patients undergoing CRT for advanced HF and 10 control patients who underwent catheter ablation for supraventricular arrhythmia but not CRT. Blood samples were collected before and 3 months after CRT. Metabolomic profiling of plasma samples was performed using gas chromatography–mass spectrometry and nuclear magnetic resonance.
Mayo Clinic
DepartmentDepartment of Medicine
Last NameCha
First NameYong-Mei
Submit Date2015-05-14
Num Groups3
Total Subjects24
Raw Data AvailableNo
Raw Data File Type(s)d
Analysis Type DetailGC-MS
Release Date2015-06-28
Release Version1
Yong-Mei Cha Yong-Mei Cha application/zip

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Treatment ID:TR000191
Treatment Summary:Heart failure|3-month follow up after cardiac resynchronization therapy (CRT)|Controls
Treatment Protocol Comments:All HF patients underwent a baseline evaluation before CRT, including assessment of New York Heart Association (NYHA) functional class, concomitant cardiovascular conditions (e.g., hypertension, coronary artery disease, and diabetes mellitus), electrocardiographic QRS duration and morphologic characteristics, and transthoracic echocardiography. Echocardiographic parameters included LV end-systolic and diastolic dimensions, LVEF, and pulmonary artery systolic pressure. Medication use was recorded and confirmed that patients were taking optimal medication dose for HF. Patients continued on stable medication dosage during the study.|The HF patients returned for a clinical follow-up 3 months after CRT. The NYHA functional class was reassessed, and echocardiography was repeated.|Ten age-matched control patients underwent catheter ablation for supraventricular arrhythmia with a normal left ventricular ejection fraction (LVEF) of greater than 55%.