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MGP000073

UniProt Annotations

Entry Information
Gene Nameadrenomedullin
Protein EntryADML_HUMAN
UniProt IDP35318
SpeciesHuman
Comments
Comment typeDescription
FunctionAM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
SimilarityBelongs to the adrenomedullin family. {ECO:0000305}.
Subcellular LocationSecreted.
Tissue SpecificityHighest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adm/";
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