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MGP000080

Record overview

MGPD IDMGP000080
Gene ID147
SpeciesHomo sapiens (Human)
Gene Nameadrenoceptor alpha 1B
Gene Symbol ADRA1B
SynonymsADRA1; ALPHA1BAR;
Alternate namesalpha-1B adrenergic receptor; alpha-1B adrenoceptor; alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; adrenergic, alpha-1B-, receptor;
Chromosome5
Map Location5q33.3
SummaryAlpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ADRA1B

Proteins

alpha-1B adrenergic receptor
Refseq ID:NP_000670
Protein GI:4501959
UniProt ID:P35368
mRNA ID:NM_000679
Length:520
RefSeq Status:
MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLP
FSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEE
PFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERS
QSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAA
DVANGQPGFKSNMPLAPGQF
 
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