MGP Database

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MGP000080

UniProt Annotations

Entry Information
Gene Nameadrenoceptor alpha 1B
Protein EntryADA1B_HUMAN
UniProt IDP35368
SpeciesHuman
Comments
Comment typeDescription
FunctionThis alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.
SimilarityBelongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationNucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
SubunitHomo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. {ECO:0000269|PubMed:22120526}.
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