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MGP000100

Record overview

MGPD IDMGP000100
Gene ID183
SpeciesHomo sapiens (Human)
Gene Nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Gene Symbol AGT
SynonymsANHU; SERPINA8;
Alternate namesangiotensinogen; serpin A8; angiotensin I; angiotensin II; pre-angiotensinogen; alpha-1 antiproteinase, antitrypsin; serine (or cysteine) proteinase inhibitor;
Chromosome1
Map Location1q42.2
SummaryThe protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for AGT

Proteins

angiotensinogen preproprotein
Refseq ID:NP_000020
Protein GI:4557287
UniProt ID:P01019
mRNA ID:NM_000029
Length:485
RefSeq Status:
MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDK
LRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQ
AQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEF
WVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAE
LPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA
 
sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3411
peptide sequence: 
MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAG

mat_peptide: 34..43
product: angiotensin I
calculated_mol_wt: 1296
peptide sequence: 
DRVYIHPFHL

mat_peptide: 34..41
product: angiotensin II
exception: alternative processing
calculated_mol_wt: 1046
peptide sequence: 
DRVYIHPF

mat_peptide: 35..41
product: angiotensin III
exception: alternative processing
calculated_mol_wt: 931
peptide sequence: 
RVYIHPF
 
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