MGP Database

MGP000100

Ontology/Pathway Information

Entrez Gene ID	183
Gene Name	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Gene Symbol	AGT
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0072562	IDA:UniProtKB	C	blood microparticle
GO:0005737	IEA:Ensembl	C	cytoplasm
GO:0005576	NAS:UniProtKB	C	extracellular region
GO:0005615	IDA:UniProtKB	C	extracellular space
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0008083	TAS:BHF-UCL	F	growth factor activity
GO:0005179	ISS:BHF-UCL	F	hormone activity
GO:0004867	IBA:RefGenome	F	serine-type endopeptidase inhibitor activity
GO:0016176	TAS:BHF-UCL	F	superoxide-generating NADPH oxidase activator activity
GO:0031702	IPI:BHF-UCL	F	type 1 angiotensin receptor binding
GO:0031703	IPI:BHF-UCL	F	type 2 angiotensin receptor binding
GO:0007250	IEA:Ensembl	P	activation of NF-kappaB-inducing kinase activity
GO:0007202	IEA:Ensembl	P	activation of phospholipase C activity
GO:0007568	IEA:Ensembl	P	aging
GO:0002003	TAS:Reactome	P	angiotensin maturation
GO:0003051	IEA:Ensembl	P	angiotensin-mediated drinking behavior
GO:0001998	IEA:Ensembl	P	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0014824	IEA:Ensembl	P	artery smooth muscle contraction
GO:0048143	IEA:Ensembl	P	astrocyte activation
GO:0001568	IEA:Ensembl	P	blood vessel development
GO:0001974	TAS:BHF-UCL	P	blood vessel remodeling
GO:0001658	IEA:Ensembl	P	branching involved in ureteric bud morphogenesis
GO:0035411	IEA:Ensembl	P	catenin import into nucleus
GO:0007267	TAS:ProtInc	P	cell-cell signaling
GO:0061049	IEA:Ensembl	P	cell growth involved in cardiac muscle cell development
GO:0007160	IEA:Ensembl	P	cell-matrix adhesion
GO:0044255	TAS:Reactome	P	cellular lipid metabolic process
GO:0044267	TAS:Reactome	P	cellular protein metabolic process
GO:0071260	IEA:Ensembl	P	cellular response to mechanical stimulus
GO:0006883	IEA:Ensembl	P	cellular sodium ion homeostasis
GO:0050663	IEA:Ensembl	P	cytokine secretion
GO:0070371	IEA:Ensembl	P	ERK1 and ERK2 cascade
GO:0008065	IEA:Ensembl	P	establishment of blood-nerve barrier
GO:0007588	IEA:Ensembl	P	excretion
GO:0030198	IEA:Ensembl	P	extracellular matrix organization
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0048144	IEA:Ensembl	P	fibroblast proliferation
GO:0007186	IDA:BHF-UCL	P	G-protein coupled receptor signaling pathway
GO:0007199	TAS:BHF-UCL	P	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0001822	IMP:BHF-UCL	P	kidney development
GO:0034374	NAS:BHF-UCL	P	low-density lipoprotein particle remodeling
GO:0016525	IEA:Ensembl	P	negative regulation of angiogenesis
GO:0030308	IEA:Ensembl	P	negative regulation of cell growth
GO:0008285	IEA:Ensembl	P	negative regulation of cell proliferation
GO:0010951	IBA:RefGenome	P	negative regulation of endopeptidase activity
GO:0043524	IEA:Ensembl	P	negative regulation of neuron apoptotic process
GO:0051387	IDA:BHF-UCL	P	negative regulation of neurotrophin TRK receptor signaling pathway
GO:2000650	TAS:BHF-UCL	P	negative regulation of sodium ion transmembrane transporter activity
GO:0034104	IEA:Ensembl	P	negative regulation of tissue remodeling
GO:0007263	TAS:BHF-UCL	P	nitric oxide mediated signal transduction
GO:0001543	IEA:Ensembl	P	ovarian follicle rupture
GO:0030432	IEA:Ensembl	P	peristalsis
GO:0007200	NAS:BHF-UCL	P	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0010535	IMP:UniProtKB	P	positive regulation of activation of JAK2 kinase activity
GO:0090190	IDA:UniProtKB	P	positive regulation of branching involved in ureteric bud morphogenesis
GO:0010613	ISS:BHF-UCL	P	positive regulation of cardiac muscle hypertrophy
GO:0032270	IDA:BHF-UCL	P	positive regulation of cellular protein metabolic process
GO:0010873	IDA:BHF-UCL	P	positive regulation of cholesterol esterification
GO:0001819	TAS:BHF-UCL	P	positive regulation of cytokine production
GO:0010595	IDA:BHF-UCL	P	positive regulation of endothelial cell migration
GO:0045742	IDA:BHF-UCL	P	positive regulation of epidermal growth factor receptor signaling pathway
GO:0003331	IEA:Ensembl	P	positive regulation of extracellular matrix constituent secretion
GO:2001238	IDA:BHF-UCL	P	positive regulation of extrinsic apoptotic signaling pathway
GO:0045723	IEA:Ensembl	P	positive regulation of fatty acid biosynthetic process
GO:0048146	ISS:BHF-UCL	P	positive regulation of fibroblast proliferation
GO:0050729	TAS:BHF-UCL	P	positive regulation of inflammatory response
GO:0010744	IC:BHF-UCL	P	positive regulation of macrophage derived foam cell differentiation
GO:0043410	IEA:Ensembl	P	positive regulation of MAPK cascade
GO:0040018	IEA:Ensembl	P	positive regulation of multicellular organism growth
GO:0033864	TAS:BHF-UCL	P	positive regulation of NAD(P)H oxidase activity
GO:0051092	TAS:BHF-UCL	P	positive regulation of NF-kappaB transcription factor activity
GO:0045429	IEA:Ensembl	P	positive regulation of nitric oxide biosynthetic process
GO:0046622	IEA:Ensembl	P	positive regulation of organ growth
GO:0050731	IDA:BHF-UCL	P	positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068	IDA:BHF-UCL	P	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0061098	IMP:UniProtKB	P	positive regulation of protein tyrosine kinase activity
GO:2000379	TAS:BHF-UCL	P	positive regulation of reactive oxygen species metabolic process
GO:0035815	IEA:Ensembl	P	positive regulation of renal sodium excretion
GO:0032930	IEA:Ensembl	P	positive regulation of superoxide anion generation
GO:0045893	IDA:UniProtKB	P	positive regulation of transcription, DNA-templated
GO:0045909	IEA:Ensembl	P	positive regulation of vasodilation
GO:0002034	TAS:BHF-UCL	P	regulation of blood vessel size by renin-angiotensin
GO:0002016	NAS:BHF-UCL	P	regulation of blood volume by renin-angiotensin
GO:0051924	IEA:Ensembl	P	regulation of calcium ion transport
GO:0001558	NAS:BHF-UCL	P	regulation of cell growth
GO:0042127	NAS:BHF-UCL	P	regulation of cell proliferation
GO:0048169	IEA:Ensembl	P	regulation of long-term neuronal synaptic plasticity
GO:0014061	IEA:Ensembl	P	regulation of norepinephrine secretion
GO:0030162	IBA:RefGenome	P	regulation of proteolysis
GO:0002019	NAS:BHF-UCL	P	regulation of renal output by angiotensin
GO:0035813	NAS:BHF-UCL	P	regulation of renal sodium excretion
GO:0051969	IEA:Ensembl	P	regulation of transmission of nerve impulse
GO:0019229	NAS:BHF-UCL	P	regulation of vasoconstriction
GO:0001999	IEA:Ensembl	P	renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
GO:0003014	IDA:UniProtKB	P	renal system process
GO:0002018	NAS:BHF-UCL	P	renin-angiotensin regulation of aldosterone production
GO:0009409	IEA:Ensembl	P	response to cold
GO:0014873	ISS:BHF-UCL	P	response to muscle activity involved in regulation of muscle adaptation
GO:0009651	IEA:Ensembl	P	response to salt stress
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0051145	IEA:Ensembl	P	smooth muscle cell differentiation
GO:0048659	IEA:Ensembl	P	smooth muscle cell proliferation
GO:0051403	IEA:Ensembl	P	stress-activated MAPK cascade
GO:0070471	IEA:Ensembl	P	uterine smooth muscle contraction
GO:0042311	IEA:Ensembl	P	vasodilation

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_22279	Fatty acid, triacylglycerol, and ketone body metabolism
REACT_19231	G alpha (i) signalling events
REACT_18283	G alpha (q) signalling events
REACT_120966	Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_111217	Metabolism
REACT_147707	Metabolism of Angiotensinogen to Angiotensins
REACT_22258	Metabolism of lipids and lipoproteins
REACT_17015	Metabolism of proteins
REACT_160078	Peptide hormone metabolism
REACT_14819	Peptide ligand-binding receptors
REACT_116145	PPARA activates gene expression
REACT_19241	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction

SMP Pathway Links

SMP ID	Description
SMP00587	Angiotensin Metabolism
SMP00145	Benazepril Action Pathway
SMP00158	Candesartan Action Pathway
SMP00146	Captopril Action Pathway
SMP00147	Cilazapril Action Pathway
SMP00148	Enalapril Action Pathway
SMP00159	Eprosartan Action Pathway
SMP00160	Forasartan Action Pathway
SMP00149	Fosinopril Action Pathway
SMP00161	Irbesartan Action Pathway
SMP00150	Lisinopril Action Pathway
SMP00162	Losartan Action Pathway
SMP00151	Moexipril Action Pathway
SMP00163	Olmesartan Action Pathway
SMP00152	Perindopril Action Pathway
SMP00153	Quinapril Action Pathway
SMP00154	Ramipril Action Pathway
SMP00155	Rescinnamine Action Pathway
SMP00156	Spirapril Action Pathway
SMP00164	Telmisartan Action Pathway
SMP00733	Temocapril Action Pathway
SMP00157	Trandolapril Action Pathway
SMP00165	Valsartan Action Pathway