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MGP000101

Record overview

MGPD IDMGP000101
Gene ID185
SpeciesHomo sapiens (Human)
Gene Nameangiotensin II receptor, type 1
Gene Symbol AGTR1
SynonymsAT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B;
Alternate namestype-1 angiotensin II receptor; type-1B angiotensin II receptor;
Chromosome3
Map Location3q24
SummaryAngiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
OrthologsView orthologs and multiple alignments for AGTR1

Proteins

type-1 angiotensin II receptor isoform 1
Refseq ID:NP_000676
Protein GI:4501997
UniProt ID:P30556
mRNA ID:NM_000685
Length:359
RefSeq Status:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYL
CKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKN
ILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
 
type-1 angiotensin II receptor isoform 1
Refseq ID:NP_033611
Protein GI:6715583
UniProt ID:P30556
mRNA ID:NM_009585
Length:359
RefSeq Status:
Protein sequence is identical to GI:4501997 (mRNA isoform)
 
type-1 angiotensin II receptor isoform 2
Refseq ID:NP_114038
Protein GI:395455057
UniProt ID:Q6NUP5
mRNA ID:NM_031850
Length:394
RefSeq Status:
MKKMNHKSTDSPKAPQLRGGVFDIVFATNSTQVIKMILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASV
FLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAII
HRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVL
IQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
 
type-1 angiotensin II receptor isoform 2
Refseq ID:NP_004826
Protein GI:395455058
UniProt ID:P30556
mRNA ID:NM_004835
Length:394
RefSeq Status:
Protein sequence is identical to GI:395455057 (mRNA isoform)
 
type-1 angiotensin II receptor isoform 3
Refseq ID:NP_114438
Protein GI:395455047
UniProt ID:
mRNA ID:NM_032049
Length:388
RefSeq Status:
MLTFTSECGCTTFGVFDIVFATNSTQVIKMILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLA
LADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFF
IENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGII
RDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
 
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