MGP Database

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MGP000101

Ontology/Pathway Information

Entrez Gene ID185
Gene Nameangiotensin II receptor, type 1
Gene Symbol AGTR1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016021 NAS:UniProtKBCintegral component of membrane
GO:0005887 IC:BHF-UCLCintegral component of plasma membrane
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0004945 IDA:UniProtKBFangiotensin type II receptor activity
GO:0001596 IDA:BHF-UCLFangiotensin type I receptor activity
GO:0031711 IPI:BHF-UCLFbradykinin receptor binding
GO:0046982 IPI:BHF-UCLFprotein heterodimerization activity
GO:0038166 IDA:GOCPangiotensin-activated signaling pathway
GO:0019722 IDA:BHF-UCLPcalcium-mediated signaling
GO:0060326 IDA:UniProtKBPcell chemotaxis
GO:0007186 IDA:BHF-UCLPG-protein coupled receptor signaling pathway
GO:0001822 IMP:BHF-UCLPkidney development
GO:0034374 NAS:BHF-UCLPlow-density lipoprotein particle remodeling
GO:0086097 IDA:GOCPphospholipase C-activating angiotensin-activated signaling pathway
GO:0007200 NAS:BHF-UCLPphospholipase C-activating G-protein coupled receptor signaling pathway
GO:0032270 IMP:BHF-UCLPpositive regulation of cellular protein metabolic process
GO:0010873 IMP:BHF-UCLPpositive regulation of cholesterol esterification
GO:0007204 IDA:BHF-UCLPpositive regulation of cytosolic calcium ion concentration
GO:0051482 IDA:BHF-UCLPpositive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0050729 TAS:BHF-UCLPpositive regulation of inflammatory response
GO:0010744 IC:BHF-UCLPpositive regulation of macrophage derived foam cell differentiation
GO:0033864 TAS:BHF-UCLPpositive regulation of NAD(P)H oxidase activity
GO:0032430 IMP:BHF-UCLPpositive regulation of phospholipase A2 activity
GO:2000379 TAS:BHF-UCLPpositive regulation of reactive oxygen species metabolic process
GO:0002034 IC:BHF-UCLPregulation of blood vessel size by renin-angiotensin
GO:0001558 NAS:BHF-UCLPregulation of cell growth
GO:0042127 NAS:BHF-UCLPregulation of cell proliferation
GO:0050727 IC:BHF-UCLPregulation of inflammatory response
GO:0035813 NAS:BHF-UCLPregulation of renal sodium excretion
GO:0003081 IC:BHF-UCLPregulation of systemic arterial blood pressure by renin-angiotensin
GO:0019229 IDA:BHF-UCLPregulation of vasoconstriction
GO:0042312 IC:BHF-UCLPregulation of vasodilation
GO:0002018 NAS:BHF-UCLPrenin-angiotensin regulation of aldosterone production
GO:0007266 IDA:UniProtKBPRho protein signal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14819Peptide ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00587Angiotensin Metabolism
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00145Benazepril Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00158Candesartan Action Pathway
SMP00146Captopril Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00147Cilazapril Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00148Enalapril Action Pathway
SMP00661Epinephrine Action Pathway
SMP00159Eprosartan Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00160Forasartan Action Pathway
SMP00149Fosinopril Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00161Irbesartan Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00150Lisinopril Action Pathway
SMP00162Losartan Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00151Moexipril Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00163Olmesartan Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00152Perindopril Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00153Quinapril Action Pathway
SMP00323Quinidine Action Pathway
SMP00154Ramipril Action Pathway
SMP00155Rescinnamine Action Pathway
SMP00660Sotalol Action Pathway
SMP00156Spirapril Action Pathway
SMP00164Telmisartan Action Pathway
SMP00733Temocapril Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00157Trandolapril Action Pathway
SMP00165Valsartan Action Pathway
SMP00375Verapamil Action Pathway
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