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MGP000101

UniProt Annotations

Entry Information
Gene Nameangiotensin II receptor, type 1
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
DiseaseRenal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269|PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionReceptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.
InteractionP01019:AGT; NbExp=2; IntAct=EBI-6623016, EBI-6622938;
PtmC-terminal Ser or Thr residues may be phosphorylated.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts with MAS1 (Probable). Interacts with ARRB1 (By similarity). {ECO:0000250, ECO:0000305}.
Tissue SpecificityLiver, lung, adrenal and adrenocortical adenomas.
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGTR1";
Web ResourceName=Wikipedia; Note=Angiotensin receptor entry; URL="http://en.wikipedia.org/wiki/Angiotensin_receptor";
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