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MGP000127

Record overview

MGPD IDMGP000127
Gene ID231
SpeciesHomo sapiens (Human)
Gene Namealdo-keto reductase family 1, member B1 (aldose reductase)
Gene Symbol AKR1B1
SynonymsAR; ADR; ALR2; ALDR1;
Alternate namesaldose reductase; Lii5-2 CTCL tumor antigen; aldehyde reductase 1; aldo-keto reductase family 1 member B1; low Km aldose reductase;
Chromosome7
Map Location7q35
EC Number1.1.1.21
SummaryThis gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
OrthologsView orthologs and multiple alignments for AKR1B1

Proteins

aldose reductase
Refseq ID:NP_001619
Protein GI:4502049
UniProt ID:P15121
mRNA ID:NM_001628
Length:316
RefSeq Status:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDL
KLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYC
QSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
 
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