MGP Database

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MGP000127

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member B1 (aldose reductase)
Protein EntryALDR_HUMAN
UniProt IDP15121
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAlditol + NAD(P)(+) = aldose + NAD(P)H.
Enzyme RegulationCys-299 may regulate the kinetic and inhibition properties of the enzyme, but does not participate in catalysis. {ECO:0000269|PubMed:8343525}.
FunctionCatalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
SimilarityBelongs to the aldo/keto reductase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitMonomer. {ECO:0000269|PubMed:15146478, ECO:0000269|PubMed:15272156, ECO:0000269|PubMed:16337231, ECO:0000269|PubMed:17368668, ECO:0000269|PubMed:17418233, ECO:0000269|PubMed:17505104}.
Tissue SpecificityHighly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. {ECO:0000269|PubMed:8435445}.
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