MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000173

Record overview

MGPD IDMGP000173
Gene ID345
SpeciesHomo sapiens (Human)
Gene Nameapolipoprotein C-III
Gene Symbol APOC3
SynonymsHALP2; APOCIII;
Alternate namesapolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3;
Chromosome11
Map Location11q23.3
SummaryApolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for APOC3

Proteins

apolipoprotein C-III precursor
Refseq ID:NP_000031
Protein GI:4557323
UniProt ID:P02656
mRNA ID:NM_000040
Length:99
RefSeq Status:
MQPRVLLVVALLALLASARASEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2106
peptide sequence: 
MQPRVLLVVALLALLASARA

mat_peptide: 21..99
product: apolipoprotein C-III
calculated_mol_wt: 8765
peptide sequence: 
SEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA
 
  logo