MGP Database

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MGP000173

UniProt Annotations

Entry Information
Gene Nameapolipoprotein C-III
Protein EntryAPOC3_HUMAN
UniProt IDP02656
SpeciesHuman
Comments
Comment typeDescription
DiseaseHyperalphalipoproteinemia 2 (HALP2) [MIM:614028]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. {ECO:0000269|PubMed:2022742}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionComponent of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. {ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}.
PtmThe most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal- GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. {ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:23527852, ECO:0000269|PubMed:3123586}.
SimilarityBelongs to the apolipoprotein C3 family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}.
Tissue SpecificityLiver. {ECO:0000269|PubMed:6328445}.
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