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MGP000230

UniProt Annotations

Entry Information
Gene Nameactivating transcription factor 3
Protein EntryATF3_HUMAN
UniProt IDP18847
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=ATF3; IsoId=P18847-1; Sequence=Displayed; Name=2; Synonyms=ATF3-delta-Zip; IsoId=P18847-2; Sequence=VSP_000592; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=ATF3-delta-Zip2a/TF3-delta-Zip2b; IsoId=P18847-3; Sequence=VSP_043150; Note=Stress-induced isoform, counteracts the transcriptional repression of isoform 1.; Name=4; Synonyms=ATF3-delta-Zip2c; IsoId=P18847-4; Sequence=VSP_043182, VSP_043150; Name=5; IsoId=P18847-5; Sequence=VSP_046966;
FunctionThis protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
InteractionSelf; NbExp=2; IntAct=EBI-712767, EBI-712767; Q14192:FHL2; NbExp=3; IntAct=EBI-712767, EBI-701903; Q04206:RELA; NbExp=4; IntAct=EBI-712767, EBI-73886;
SimilarityBelongs to the bZIP family. ATF subfamily. {ECO:0000305}.
SimilarityContains 1 bZIP (basic-leucine zipper) domain. {ECO:0000255|PROSITE-ProRule:PRU00978}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:12034827}.
SubunitBinds DNA as a homodimer or a heterodimer.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ATF3ID719ch1q32.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/atf3/";
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