MGP Database

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MGP000321

Ontology/Pathway Information

Entrez Gene ID650
Gene Namebone morphogenetic protein 2
Gene Symbol BMP2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:UniProtKBCcell surface
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IEA:UniProtKB-KWCextracellular space
GO:0070700 IDA:MGIFBMP receptor binding
GO:0019211 IDA:MGIFphosphatase activator activity
GO:0046982 IDA:MGIFprotein heterodimerization activity
GO:0005102 TAS:ProtIncFreceptor binding
GO:0004745 ISS:UniProtKBFretinol dehydrogenase activity
GO:0046332 IDA:BHF-UCLFSMAD binding
GO:0000187 IDA:AgBasePactivation of MAPK activity
GO:0003181 ISS:UniProtKBPatrioventricular valve morphogenesis
GO:0030509 IDA:BHF-UCLPBMP signaling pathway
GO:0003130 IDA:BHF-UCLPBMP signaling pathway involved in heart induction
GO:0030282 ISS:UniProtKBPbone mineralization
GO:0035630 IDA:BHF-UCLPbone mineralization involved in bone maturation
GO:0001658 ISS:UniProtKBPbranching involved in ureteric bud morphogenesis
GO:0060317 IDA:BHF-UCLPcardiac epithelial to mesenchymal transition
GO:0055007 IMP:BHF-UCLPcardiac muscle cell differentiation
GO:0055008 ISS:UniProtKBPcardiac muscle tissue morphogenesis
GO:0035051 IMP:BHF-UCLPcardiocyte differentiation
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0045165 ISS:UniProtKBPcell fate commitment
GO:0071773 IDA:BHF-UCLPcellular response to BMP stimulus
GO:0071407 IEA:EnsemblPcellular response to organic cyclic compound
GO:0002062 IDA:AgBasePchondrocyte differentiation
GO:0060128 ISS:UniProtKBPcorticotropin hormone secreting cell differentiation
GO:0009790 ISS:UniProtKBPembryo development
GO:0035054 ISS:UniProtKBPembryonic heart tube anterior/posterior pattern specification
GO:0003203 ISS:UniProtKBPendocardial cushion morphogenesis
GO:0001837 IDA:BHF-UCLPepithelial to mesenchymal transition
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0040007 IEA:InterProPgrowth
GO:0007507 ISS:UniProtKBPheart development
GO:0006954 ISS:UniProtKBPinflammatory response
GO:0048839 ISS:UniProtKBPinner ear development
GO:0001701 ISS:UniProtKBPin utero embryonic development
GO:0048762 IDA:UniProtKBPmesenchymal cell differentiation
GO:0072138 ISS:UniProtKBPmesenchymal cell proliferation involved in ureteric bud development
GO:0060485 IMP:BHF-UCLPmesenchyme development
GO:0032348 IDA:BHF-UCLPnegative regulation of aldosterone biosynthetic process
GO:0051042 IDA:AgBasePnegative regulation of calcium-independent cell-cell adhesion
GO:0090090 IEP:AgBasePnegative regulation of canonical Wnt signaling pathway
GO:2000726 IDA:BHF-UCLPnegative regulation of cardiac muscle cell differentiation
GO:0045786 IDA:HGNCPnegative regulation of cell cycle
GO:0008285 IDA:BHF-UCLPnegative regulation of cell proliferation
GO:2000065 IDA:BHF-UCLPnegative regulation of cortisol biosynthetic process
GO:0043569 IDA:BHF-UCLPnegative regulation of insulin-like growth factor receptor signaling pathway
GO:0010894 IDA:BHF-UCLPnegative regulation of steroid biosynthetic process
GO:0045892 IDA:BHF-UCLPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0003308 IDA:BHF-UCLPnegative regulation of Wnt signaling pathway involved in heart development
GO:0007219 ISS:UniProtKBPNotch signaling pathway
GO:0042475 ISS:UniProtKBPodontogenesis of dentin-containing tooth
GO:0009887 ISS:UniProtKBPorgan morphogenesis
GO:0001649 IDA:MGIPosteoblast differentiation
GO:0060389 IDA:BHF-UCLPpathway-restricted SMAD protein phosphorylation
GO:0060039 ISS:UniProtKBPpericardium development
GO:0043065 IDA:MGIPpositive regulation of apoptotic process
GO:0048711 ISS:UniProtKBPpositive regulation of astrocyte differentiation
GO:0030501 IDA:BHF-UCLPpositive regulation of bone mineralization
GO:0061036 IDA:MGIPpositive regulation of cartilage development
GO:0030335 ISS:UniProtKBPpositive regulation of cell migration
GO:0001938 IDA:UniProtKBPpositive regulation of endothelial cell proliferation
GO:0010718 IDA:BHF-UCLPpositive regulation of epithelial to mesenchymal transition
GO:0070374 IDA:DFLATPpositive regulation of ERK1 and ERK2 cascade
GO:0045600 ISS:UniProtKBPpositive regulation of fat cell differentiation
GO:0010628 IDA:UniProtKBPpositive regulation of gene expression
GO:0043410 IDA:DFLATPpositive regulation of MAPK cascade
GO:0045666 ISS:UniProtKBPpositive regulation of neuron differentiation
GO:0042482 ISS:UniProtKBPpositive regulation of odontogenesis
GO:0045778 IDA:MGIPpositive regulation of ossification
GO:0045669 IDA:BHF-UCLPpositive regulation of osteoblast differentiation
GO:0033690 ISS:UniProtKBPpositive regulation of osteoblast proliferation
GO:1900745 IDA:DFLATPpositive regulation of p38MAPK cascade
GO:0010862 IDA:UniProtKBPpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010922 IDA:MGIPpositive regulation of phosphatase activity
GO:0001934 IDA:MGIPpositive regulation of protein phosphorylation
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:1901522 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:0030177 ISS:UniProtKBPpositive regulation of Wnt signaling pathway
GO:0060804 ISS:UniProtKBPpositive regulation of Wnt signaling pathway by BMP signaling pathway
GO:0031648 IEA:EnsemblPprotein destabilization
GO:0006468 IDA:DFLATPprotein phosphorylation
GO:0006029 IEA:EnsemblPproteoglycan metabolic process
GO:0042487 IEA:EnsemblPregulation of odontogenesis of dentin-containing tooth
GO:0006355 IDA:HGNCPregulation of transcription, DNA-templated
GO:0001666 ISS:UniProtKBPresponse to hypoxia
GO:0001501 TAS:ProtIncPskeletal system development
GO:0060395 IDA:UniProtKBPSMAD protein signal transduction
GO:0021537 IDA:MGIPtelencephalon development
GO:0021978 ISS:UniProtKBPtelencephalon regionalization
GO:0060129 ISS:UniProtKBPthyroid-stimulating hormone-secreting cell differentiation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_150366Elastic fibre formation
REACT_118779Extracellular matrix organization
REACT_150331Molecules associated with elastic fibres
REACT_12034Signaling by BMP
REACT_111102Signal Transduction
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