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MGP000321

UniProt Annotations

Entry Information
Gene Namebone morphogenetic protein 2
Protein EntryBMP2_HUMAN
UniProt IDP12643
SpeciesHuman
Comments
Comment typeDescription
FunctionInduces cartilage and bone formation.
InteractionP36894:BMPR1A; NbExp=11; IntAct=EBI-1029262, EBI-1029237; O00238:BMPR1B; NbExp=3; IntAct=EBI-1029262, EBI-7527193; Q12841:FSTL1; NbExp=2; IntAct=EBI-1029262, EBI-2349801; Q13253:NOG; NbExp=2; IntAct=EBI-1029262, EBI-1035205;
PharmaceuticalAvailable under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures.
SimilarityBelongs to the TGF-beta family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitHomodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity). {ECO:0000250}.
Tissue SpecificityParticularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Web ResourceName=Wikipedia; Note=Bone morphogenetic protein 2 entry; URL="http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_2";
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