MGP Database

MGP000323

Record overview

MGPD ID	MGP000323
Gene ID	655
Species	Homo sapiens (Human)
Gene Name	bone morphogenetic protein 7
Gene Symbol	BMP7
Synonyms	OP-1;
Alternate names	bone morphogenetic protein 7; osteogenic protein 1;
Chromosome	20
Map Location	20q13
Summary	The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for BMP7

Proteins

bone morphogenetic protein 7 precursor

Refseq ID:	NP_001710
Protein GI:	4502427
UniProt ID:	P18075
mRNA ID:	NM_001719
Length:	431
RefSeq Status:

MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGG
QGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQE
HLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRS
QNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQ
LNAISVLYFDDSSNVILKKYRNMVVRACGCH

sig_peptide: 1..29
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3203
peptide sequence: 
MHVRSLRAAAPHSFVALWAPLFLLRSALA

mat_peptide: 293..431
product: bone morphogenetic protein 7
calculated_mol_wt: 15681
peptide sequence: 
STGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVP
KPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH