MGP Database

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MGP000323

UniProt Annotations

Entry Information
Gene Namebone morphogenetic protein 7
Protein EntryBMP7_HUMAN
UniProt IDP18075
SpeciesHuman
Comments
Comment typeDescription
Developmental StageExpressed in the developing eye, brain and ear during embryogenesis. {ECO:0000269|PubMed:20506283}.
FunctionInduces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
PharmaceuticalAvailable under the name Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.
PtmSeveral N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms. {ECO:0000269|PubMed:17977014}.
SimilarityBelongs to the TGF-beta family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitHomodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in the kidney and bladder. Lower levels seen in the brain.
Web ResourceName=Wikipedia; Note=Bone morphogenetic protein 7 entry; URL="http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_7";
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