MGP Database

MGP000414

Record overview

MGPD ID	MGP000414
Gene ID	835
Species	Homo sapiens (Human)
Gene Name	caspase 2, apoptosis-related cysteine peptidase
Gene Symbol	CASP2
Synonyms	ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57;
Alternate names	caspase-2; neural precursor cell expressed developmentally down-regulated protein 2; protease ICH-1; protein phosphatase 1, regulatory subunit 57;
Chromosome	7
Map Location	7q34-q35
EC Number	3.4.22.55
Summary	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Orthologs	View orthologs and multiple alignments for CASP2

Proteins

caspase-2 isoform 1 preproprotein

Refseq ID:	NP_116764
Protein GI:	39995059
UniProt ID:	P42575
mRNA ID:	NM_032982
Length:	452
RefSeq Status:

MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFD
AFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRG
LALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF
DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACD
MHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT

mat_peptide: 170..325
product: Caspase-2 subunit p18
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P42575.2)
calculated_mol_wt: 17498
peptide sequence: 
GPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDS
CIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDET

mat_peptide: 334..452
product: Caspase-2 subunit p13
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P42575.2)
calculated_mol_wt: 13270
peptide sequence: 
GKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMS
EYCSTLCRHLYLFPGHPPT

mat_peptide: 348..452
product: Caspase-2 subunit p12
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P42575.2)
calculated_mol_wt: 11901
peptide sequence: 
AGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFP
GHPPT

caspase-2 isoform 2

Refseq ID:	NP_001215
Protein GI:	4502575
UniProt ID:	P42575
mRNA ID:	NM_001224
Length:	312
RefSeq Status:

`MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPP LSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVT LFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGGAIGSLGHL LLFTAATASLAL`

mat_peptide: 170..325
product: Caspase-2 subunit p18
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P42575.2)
calculated_mol_wt: 17498
peptide sequence: 
GPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDS
CIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDET

mat_peptide: 334..452
product: Caspase-2 subunit p13
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P42575.2)
calculated_mol_wt: 13270
peptide sequence: 
GKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMS
EYCSTLCRHLYLFPGHPPT

mat_peptide: 348..452
product: Caspase-2 subunit p12
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P42575.2)
calculated_mol_wt: 11901
peptide sequence: 
AGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFP
GHPPT

caspase-2 isoform 3

Refseq ID:	NP_116765
Protein GI:	39995061
UniProt ID:	P42575
mRNA ID:	NM_032983
Length:	108
RefSeq Status:

`MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFD AFCEALHS`