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MGP000414

UniProt Annotations

Entry Information
Gene Namecaspase 2, apoptosis-related cysteine peptidase
Protein EntryCASP2_HUMAN
UniProt IDP42575
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Comment=Isoforms differ in the N- and C-termini.; Name=1; Synonyms=ICH-1L; IsoId=P42575-1; Sequence=Displayed; Note=Acts as a positive regulator of apoptosis.; Name=2; Synonyms=ICH-1S; IsoId=P42575-2; Sequence=VSP_000801, VSP_000802; Note=Acts as a negative regulator of apoptosis.; Name=3; Synonyms=Casp-2L-Pro; IsoId=P42575-3; Sequence=VSP_046280, VSP_046281, VSP_046282; Note=May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death.;
Catalytic ActivityStrict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.
FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
InteractionP42575-1:CASP2; NbExp=2; IntAct=EBI-520342, EBI-520357; P78560:CRADD; NbExp=9; IntAct=EBI-520342, EBI-520375; P78527:PRKDC; NbExp=4; IntAct=EBI-520342, EBI-352053;
PtmThe mature protease can process its own propeptide, but not that of other caspases. {ECO:0000269|PubMed:8654923}.
Sequence CautionSequence=AAA58959.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAO25653.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP22346.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP22349.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92877.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase C14A family. {ECO:0000305}.
SimilarityContains 1 CARD domain. {ECO:0000255|PROSITE- ProRule:PRU00046}.
SubunitHeterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. {ECO:0000269|PubMed:12920126, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:16652156}.
Tissue SpecificityExpressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/casp2/";
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