MGP Database

MGP000414

Ontology/Pathway Information

Entrez Gene ID	835
Gene Name	caspase 2, apoptosis-related cysteine peptidase
Gene Symbol	CASP2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IBA:GO_Central	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0016020	IEA:Ensembl	C	membrane
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0005634	TAS:UniProtKB	C	nucleus
GO:0004197	IDA:UniProtKB	F	cysteine-type endopeptidase activity
GO:0097153	IEA:Ensembl	F	cysteine-type endopeptidase activity involved in apoptotic process
GO:0019899	ISS:UniProtKB	F	enzyme binding
GO:0019904	IPI:BHF-UCL	F	protein domain specific binding
GO:0007568	IEA:Ensembl	P	aging
GO:0006915	NAS:UniProtKB	P	apoptotic process
GO:0097190	TAS:UniProtKB	P	apoptotic signaling pathway
GO:0007420	IEA:Ensembl	P	brain development
GO:0071260	IEP:UniProtKB	P	cellular response to mechanical stimulus
GO:0006977	IMP:UniProtKB	P	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0035234	IEA:Ensembl	P	ectopic germ cell programmed cell death
GO:0097194	TAS:UniProtKB	P	execution phase of apoptosis
GO:0097192	IBA:GO_Central	P	extrinsic apoptotic signaling pathway in absence of ligand
GO:0008630	TAS:UniProtKB	P	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001554	IEA:Ensembl	P	luteolysis
GO:0003407	IEA:Ensembl	P	neural retina development
GO:0048011	TAS:Reactome	P	neurotrophin TRK receptor signaling pathway
GO:0043065	IDA:UniProtKB	P	positive regulation of apoptotic process
GO:2001235	IEA:Ensembl	P	positive regulation of apoptotic signaling pathway
GO:0043525	IEA:Ensembl	P	positive regulation of neuron apoptotic process
GO:0016485	IDA:BHF-UCL	P	protein processing
GO:0043281	TAS:Reactome	P	regulation of cysteine-type endopeptidase activity involved in apoptotic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_13720	Cell death signalling via NRAGE, NRIF and NADE
REACT_6900	Immune System
REACT_6802	Innate Immune System
REACT_13526	NADE modulates death signalling
REACT_75776	NOD1/2 Signaling Pathway
REACT_75913	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_13776	p75 NTR receptor-mediated signalling
REACT_11061	Signalling by NGF
REACT_111102	Signal Transduction