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MGP000416

Record overview

MGPD IDMGP000416
Gene ID837
SpeciesHomo sapiens (Human)
Gene Namecaspase 4, apoptosis-related cysteine peptidase
Gene Symbol CASP4
SynonymsTX; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II;
Alternate namescaspase-4; CASP-4; ICE(rel)-II; apoptotic cysteine protease Mih1/TX; caspase 4, apoptosis-related cysteine protease; protease ICH-2; protease TX;
Chromosome11
Map Location11q22.2-q22.3
EC Number3.4.22.57
SummaryThis gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CASP4

Proteins

caspase-4 isoform alpha precursor
Refseq ID:NP_001216
Protein GI:4502577
UniProt ID:P49662
mRNA ID:NM_001225
Length:377
RefSeq Status:
MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESG
ESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSS
DSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF
IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
 
mat_peptide: 81..270
product: caspase-4 isoform alpha large subunit
calculated_mol_wt: 21535
peptide sequence: 
QISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRD

mat_peptide: 290..377
product: caspase-4 isoform alpha small subunit
calculated_mol_wt: 10411
peptide sequence: 
AVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
 
caspase-4 isoform gamma precursor
Refseq ID:NP_150649
Protein GI:15451910
UniProt ID:P49662
mRNA ID:NM_033306
Length:321
RefSeq Status:
MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGAD
FDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQ
ACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK
AQMPTIERLSMTRYFYLFPGN
 
mat_peptide: 81..270
product: caspase-4 isoform alpha large subunit
calculated_mol_wt: 21535
peptide sequence: 
QISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRD

mat_peptide: 290..377
product: caspase-4 isoform alpha small subunit
calculated_mol_wt: 10411
peptide sequence: 
AVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN

mat_peptide: 25..214
product: caspase-4 isoform beta large subunit
calculated_mol_wt: 21535
peptide sequence: 
QISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRD

mat_peptide: 234..321
product: caspase-4 isoform beta small subunit
calculated_mol_wt: 10411
peptide sequence: 
AVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
 
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