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MGP000416

UniProt Annotations

Entry Information
Gene Namecaspase 4, apoptosis-related cysteine peptidase
Protein EntryCASP4_HUMAN
UniProt IDP49662
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49662-1; Sequence=Displayed; Name=2; IsoId=P49662-2; Sequence=VSP_043495;
Catalytic ActivityStrict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-. {ECO:0000269|Ref.14}.
Enzyme RegulationInhibited by the effector protein NleF that is produced by pathogenic E.coli; this inhibits apoptosis. {ECO:0000269|Ref.14}.
FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1. {ECO:0000269|PubMed:15123740, ECO:0000269|Ref.14}.
PtmThe two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
SimilarityBelongs to the peptidase C14A family. {ECO:0000305}.
SimilarityContains 1 CARD domain. {ECO:0000255|PROSITE- ProRule:PRU00046}.
Subcellular LocationEndoplasmic reticulum membrane. Mitochondrion.
SubunitHeterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit (By similarity). Interacts with NleF from pathogenic E.coli. Interacts with TMEM214, the interaction is required for ER membrane localization. {ECO:0000250, ECO:0000269|PubMed:23661706, ECO:0000269|Ref.14}.
Tissue SpecificityWidely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/casp4/";
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