MGP Database

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MGP000438

Record overview

MGPD IDMGP000438
Gene ID890
SpeciesHomo sapiens (Human)
Gene Namecyclin A2
Gene Symbol CCNA2
SynonymsCCN1; CCNA;
Alternate namescyclin-A2; cyclin-A;
Chromosome4
Map Location4q27
SummaryThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CCNA2

Proteins

cyclin-A2
Refseq ID:NP_001228
Protein GI:4502613
UniProt ID:P20248
mRNA ID:NM_001237
Length:432
RefSeq Status:
MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFT
IHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIVLEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYM
KKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLK
VLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLK
APQHAQQSIREKYKNSKYHGVSLLNPPETLNL
 
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