MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000438

UniProt Annotations

Entry Information
Gene Namecyclin A2
Protein EntryCCNA2_HUMAN
UniProt IDP20248
SpeciesHuman
Comments
Comment typeDescription
Developmental StageAccumulates steadily during G2 and is abruptly destroyed at mitosis.
FunctionEssential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
InteractionP03070:- (xeno); NbExp=2; IntAct=EBI-457097, EBI-617698; P24941:CDK2; NbExp=19; IntAct=EBI-457097, EBI-375096; P38936:CDKN1A; NbExp=2; IntAct=EBI-457097, EBI-375077; P46527:CDKN1B; NbExp=13; IntAct=EBI-457097, EBI-519280; Q96PU4:UHRF2; NbExp=2; IntAct=EBI-457097, EBI-625304;
PtmPolyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity). {ECO:0000250}.
SimilarityBelongs to the cyclin family. Cyclin AB subfamily. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:17698606}. Cytoplasm {ECO:0000269|PubMed:17698606}. Note=Cytoplasmic when associated with SCAPER.
SubunitInteracts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER. {ECO:0000269|PubMed:17698606}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccna2/";
  logo