MGP Database

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MGP000454

Record overview

MGPD IDMGP000454
Gene ID926
SpeciesHomo sapiens (Human)
Gene NameCD8b molecule
Gene Symbol CD8B
SynonymsLY3; P37; LEU2; LYT3; CD8B1;
Alternate namesT-cell surface glycoprotein CD8 beta chain; CD8 antigen, beta polypeptide 1 (p37); T lymphocyte surface glycoprotein beta chain;
Chromosome2
Map Location2p12
SummaryThe CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
OrthologsView orthologs and multiple alignments for CD8B

Proteins

T-cell surface glycoprotein CD8 beta chain isoform 2 precursor
Refseq ID:NP_757362
Protein GI:27886639
UniProt ID:P10966
mRNA ID:NM_172213
Length:243
RefSeq Status:
MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFI
LNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRA
RLRFMKQPQGEGISGTFVPQCLHGYYSNTTTSQKLLNPWILKT
 
sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..198
product: T-cell surface glycoprotein CD8 beta chain isoform 6
calculated_mol_wt: 19866
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGLKGKVYQEPLSPNACMDTTAILQPHRSCLTHGS

sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..210
product: T-cell surface glycoprotein CD8 beta chain isoform 5
calculated_mol_wt: 21351
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK

sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..243
product: T-cell surface glycoprotein CD8 beta chain isoform 2
calculated_mol_wt: 24875
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQPQGEGISGTFVPQC
LHGYYSNTTTSQKLLNPWILKT
 
T-cell surface glycoprotein CD8 beta chain isoform 3 precursor
Refseq ID:NP_742099
Protein GI:27886635
UniProt ID:P10966
mRNA ID:NM_172101
Length:221
RefSeq Status:
MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFI
LNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRA
RLRFMKQLRLHPLEKCSRMDY
 
sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..198
product: T-cell surface glycoprotein CD8 beta chain isoform 6
calculated_mol_wt: 19866
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGLKGKVYQEPLSPNACMDTTAILQPHRSCLTHGS

sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..210
product: T-cell surface glycoprotein CD8 beta chain isoform 5
calculated_mol_wt: 21351
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK

sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..243
product: T-cell surface glycoprotein CD8 beta chain isoform 2
calculated_mol_wt: 24875
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQPQGEGISGTFVPQC
LHGYYSNTTTSQKLLNPWILKT

sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..213
product: T-cell surface glycoprotein CD8 beta chain isoform 4
calculated_mol_wt: 21905
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGRRRRARLRFMKQPQGEGISGTFVPQCLHGYYSNTTTSQKLLNPWILKT

sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..221
product: T-cell surface glycoprotein CD8 beta chain isoform 3
calculated_mol_wt: 22656
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQLRLHPLEKCSRMDY
 
T-cell surface glycoprotein CD8 beta chain isoform 4 precursor
Refseq ID:NP_742100
Protein GI:27886637
UniProt ID:P10966
mRNA ID:NM_172102
Length:213
RefSeq Status:
MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFI
LNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGRRRRARLRFMKQPQGEGISGTFVPQCLHGYYSNTT
TSQKLLNPWILKT
 
sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..198
product: T-cell surface glycoprotein CD8 beta chain isoform 6
calculated_mol_wt: 19866
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGLKGKVYQEPLSPNACMDTTAILQPHRSCLTHGS

sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..210
product: T-cell surface glycoprotein CD8 beta chain isoform 5
calculated_mol_wt: 21351
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK

sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..243
product: T-cell surface glycoprotein CD8 beta chain isoform 2
calculated_mol_wt: 24875
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQPQGEGISGTFVPQC
LHGYYSNTTTSQKLLNPWILKT

sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..213
product: T-cell surface glycoprotein CD8 beta chain isoform 4
calculated_mol_wt: 21905
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGRRRRARLRFMKQPQGEGISGTFVPQCLHGYYSNTTTSQKLLNPWILKT
 
T-cell surface glycoprotein CD8 beta chain isoform 5 precursor
Refseq ID:NP_004922
Protein GI:4826667
UniProt ID:P10966
mRNA ID:NM_004931
Length:210
RefSeq Status:
MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFI
LNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRA
RLRFMKQFYK
 
sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..198
product: T-cell surface glycoprotein CD8 beta chain isoform 6
calculated_mol_wt: 19866
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGLKGKVYQEPLSPNACMDTTAILQPHRSCLTHGS

sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..210
product: T-cell surface glycoprotein CD8 beta chain isoform 5
calculated_mol_wt: 21351
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK
 
T-cell surface glycoprotein CD8 beta chain isoform 6 precursor
Refseq ID:NP_001171571
Protein GI:296010933
UniProt ID:P10966
mRNA ID:NM_001178100
Length:198
RefSeq Status:
MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFI
LNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGLKGKVYQEPLSPNACMDTTAILQPHRSCLTHGS
 
sig_peptide: 1..21
calculated_mol_wt: 2389
peptide sequence: 
MRPRLWLLLAAQLTVLHGNSV

mat_peptide: 22..198
product: T-cell surface glycoprotein CD8 beta chain isoform 6
calculated_mol_wt: 19866
peptide sequence: 
LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS
PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGLKGKVYQEPLSPNACMDTTAILQPHRSCLTHGS
 
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