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MGP000454

UniProt Annotations

Entry Information
Gene NameCD8b molecule
Protein EntryCD8B_HUMAN
UniProt IDP10966
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=8; Name=1; Synonyms=M-1, Mbeta1; IsoId=P10966-1; Sequence=Displayed; Name=2; Synonyms=M-3, Mbeta2; IsoId=P10966-2; Sequence=VSP_002490; Name=3; Synonyms=S-1, Sbeta3; IsoId=P10966-3; Sequence=VSP_002492, VSP_002493; Name=4; Synonyms=M-2; IsoId=P10966-4; Sequence=VSP_002491; Name=5; Synonyms=Mbeta3; IsoId=P10966-6; Sequence=VSP_002493; Note=Ref.6 (AAI00915) sequence is in conflict in position: 213:I->V. {ECO:0000305}; Name=6; Synonyms=Sbeta1; IsoId=P10966-7; Sequence=VSP_002492; Name=7; Synonyms=Sbeta4; IsoId=P10966-8; Sequence=VSP_039654; Name=8; Synonyms=Sbeta5; IsoId=P10966-9; Sequence=VSP_039655;
FunctionIdentifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
PtmPhosphorylated as a consequence of T-cell activation. {ECO:0000305}.
Sequence CautionSequence=AAD13877.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityContains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
Subcellular LocationIsoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Subcellular LocationIsoform 2: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Subcellular LocationIsoform 3: Secreted {ECO:0000305}.
Subcellular LocationIsoform 4: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Subcellular LocationIsoform 5: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Subcellular LocationIsoform 6: Secreted {ECO:0000305}.
Subcellular LocationIsoform 7: Secreted {ECO:0000305}.
Subcellular LocationIsoform 8: Secreted {ECO:0000305}.
SubunitIn general heterodimer of an alpha and a beta chain linked by two disulfide bonds.
Tissue SpecificityIsoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells. {ECO:0000269|PubMed:8436166}.
Web ResourceName=Wikipedia; Note=CD8 entry; URL="http://en.wikipedia.org/wiki/CD8";
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