MGP Database

MGP000460

Record overview

MGPD ID	MGP000460
Gene ID	942
Species	Homo sapiens (Human)
Gene Name	CD86 molecule
Gene Symbol	CD86
Synonyms	B70; B7-2; B7.2; LAB72; CD28LG2;
Alternate names	T-lymphocyte activation antigen CD86; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen);
Chromosome	3
Map Location	3q21
Summary	This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Orthologs	View orthologs and multiple alignments for CD86

Proteins

T-lymphocyte activation antigen CD86 isoform 1 precursor

Refseq ID:	NP_787058
Protein GI:	332634934
UniProt ID:	P42081
mRNA ID:	NM_175862
Length:	329
RefSeq Status:

`MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNL QIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGIMQKSQDNVTELYDVS ISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREK IHIPERSDEAQRVFKSSKTSSCDKSDTCF`

sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2977
peptide sequence: 
MDPQCTMGLSNILFVMAFLLSANFSQP

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2506
peptide sequence: 
MGLSNILFVMAFLLSGAAPLKIQA

sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3182
peptide sequence: 
MDPQCTMGLSNILFVMAFLLSGAAPLKIQA

T-lymphocyte activation antigen CD86 isoform 2 precursor

Refseq ID:	NP_008820
Protein GI:	332634929
UniProt ID:	P42081
mRNA ID:	NM_006889
Length:	323
RefSeq Status:

`MGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKG LYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGIMQKSQDNVTELYDVSISLSVS FPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREKIHIPER SDEAQRVFKSSKTSSCDKSDTCF`

sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2977
peptide sequence: 
MDPQCTMGLSNILFVMAFLLSANFSQP

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2506
peptide sequence: 
MGLSNILFVMAFLLSGAAPLKIQA

T-lymphocyte activation antigen CD86 isoform 3 precursor

Refseq ID:	NP_795711
Protein GI:	332634944
UniProt ID:	P42081
mRNA ID:	NM_176892
Length:	275
RefSeq Status:

`MGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKG LYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGIMQKSQDNVTELYDVSISLSVS FPDVTSNMTIFCILETDKTRLLSSPFSIGTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF`

sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2977
peptide sequence: 
MDPQCTMGLSNILFVMAFLLSANFSQP

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2506
peptide sequence: 
MGLSNILFVMAFLLSGAAPLKIQA

sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3182
peptide sequence: 
MDPQCTMGLSNILFVMAFLLSGAAPLKIQA

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2506
peptide sequence: 
MGLSNILFVMAFLLSGAAPLKIQA

T-lymphocyte activation antigen CD86 isoform 4 precursor

Refseq ID:	NP_001193853
Protein GI:	332634950
UniProt ID:	P42081
mRNA ID:	NM_001206924
Length:	217
RefSeq Status:

`MDPQCTMGLSNILFVMAFLLSANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGIMQKSQDNVTELYDVSISLSVSFPDVTS NMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREKIHIPERSDEAQR VFKSSKTSSCDKSDTCF`

T-lymphocyte activation antigen CD86 isoform 5
`sig_peptide: 1..27 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2977 peptide sequence: MDPQCTMGLSNILFVMAFLLSANFSQP`

Refseq ID:	NP_001193854
Protein GI:	332634954
UniProt ID:	P42081
mRNA ID:	NM_001206925
Length:	247
RefSeq Status:

`MGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEY DGIMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKC GTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF`

sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2977
peptide sequence: 
MDPQCTMGLSNILFVMAFLLSANFSQP

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2506
peptide sequence: 
MGLSNILFVMAFLLSGAAPLKIQA

sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3182
peptide sequence: 
MDPQCTMGLSNILFVMAFLLSGAAPLKIQA

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2506
peptide sequence: 
MGLSNILFVMAFLLSGAAPLKIQA