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MGP000460

UniProt Annotations

Entry Information
Gene NameCD86 molecule
Protein EntryCD86_HUMAN
UniProt IDP42081
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; IsoId=P42081-1; Sequence=Displayed; Name=2; IsoId=P42081-3; Sequence=VSP_023124; Name=3; Synonyms=CD86 deltaEC; IsoId=P42081-2; Sequence=VSP_023124, VSP_009125; Name=4; Synonyms=CD86 deltaTM; IsoId=P42081-4; Sequence=VSP_023124, VSP_040324; Name=5; IsoId=P42081-5; Sequence=VSP_047221; Note=No experimental confirmation available.; Name=6; IsoId=P42081-6; Sequence=VSP_047220; Note=No experimental confirmation available.;
FunctionReceptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
InteractionP16410:CTLA4; NbExp=3; IntAct=EBI-1030956, EBI-1030991;
PtmPolyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. {ECO:0000269|PubMed:12582153}.
SimilarityContains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
SimilarityContains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
Subcellular LocationCell membrane; Single-pass type I membrane protein.
SubunitHomodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses. {ECO:0000269|PubMed:11279501, ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:12606712, ECO:0000269|PubMed:16920215, ECO:0000305}.
Tissue SpecificityExpressed by activated B-lymphocytes and monocytes.
Web ResourceName=Wikipedia; Note=CD86 entry; URL="http://en.wikipedia.org/wiki/CD86";
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