MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000488

Record overview

MGPD IDMGP000488
Gene ID998
SpeciesHomo sapiens (Human)
Gene Namecell division cycle 42
Gene Symbol CDC42
SynonymsG25K; CDC42Hs;
Alternate namescell division control protein 42 homolog; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; GTP binding protein, 25kDa; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD));
Chromosome1
Map Location1p36.1
SummaryThe protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
OrthologsView orthologs and multiple alignments for CDC42

Proteins

cell division control protein 42 homolog isoform 1 precursor
Refseq ID:NP_001782
Protein GI:4757952
UniProt ID:P60953
mRNA ID:NM_001791
Length:191
RefSeq Status:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPE
ITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
 
mat_peptide: 1..188
product: Cell division control protein 42 homolog
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P60953.2)
calculated_mol_wt: 20933
peptide sequence: 
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPE
ITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRC
 
cell division control protein 42 homolog isoform 1 precursor
Refseq ID:NP_001034891
Protein GI:89903012
UniProt ID:P60953
mRNA ID:NM_001039802
Length:191
RefSeq Status:
Protein sequence is identical to GI:4757952 (mRNA isoform)
 
mat_peptide: 1..188
product: Cell division control protein 42 homolog
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P60953.2)
calculated_mol_wt: 20933
peptide sequence: 
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPE
ITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRC

mat_peptide: 1..188
product: Cell division control protein 42 homolog
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P60953.2)
calculated_mol_wt: 20933
peptide sequence: 
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPE
ITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRC
 
cell division control protein 42 homolog isoform 2
Refseq ID:NP_426359
Protein GI:16357472
UniProt ID:P60953
mRNA ID:NM_044472
Length:191
RefSeq Status:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPE
ITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF
 
  logo