MGP Database

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MGP000488

Ontology/Pathway Information

Entrez Gene ID998
Gene Namecell division cycle 42
Gene Symbol CDC42
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0045177 IEA:EnsemblCapical part of cell
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0036464 IDA:ParkinsonsUK-UCLCcytoplasmic ribonucleoprotein granule
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0030175 IDA:UniProtKBCfilopodium
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0000139 ISS:BHF-UCLCGolgi membrane
GO:0031256 IEA:EnsemblCleading edge membrane
GO:0016020 IDA:UniProtKBCmembrane
GO:0005815 IEA:UniProtKB-SubCellCmicrotubule organizing center
GO:0030496 IDA:UniProtKBCmidbody
GO:0072686 IDA:UniProtKBCmitotic spindle
GO:0043025 IDA:BHF-UCLCneuronal cell body
GO:0043005 IDA:BHF-UCLCneuron projection
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0030141 IEA:EnsemblCsecretory granule
GO:0051233 IDA:UniProtKBCspindle midzone
GO:0034191 IPI:BHF-UCLFapolipoprotein A-I receptor binding
GO:0003924 TAS:UniProtKBFGTPase activity
GO:0005525 IDA:MGIFGTP binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0019901 IDA:BHF-UCLFprotein kinase binding
GO:0031996 IPI:UniProtKBFthioesterase binding
GO:0030036 IDA:UniProtKBPactin cytoskeleton organization
GO:0090135 IEA:EnsemblPactin filament branching
GO:0051017 IEA:EnsemblPactin filament bundle assembly
GO:0034332 IEA:EnsemblPadherens junction organization
GO:0007411 TAS:ReactomePaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0060070 IEA:EnsemblPcanonical Wnt signaling pathway
GO:0003161 IEA:EnsemblPcardiac conduction system development
GO:0034613 IEA:EnsemblPcellular protein localization
GO:0036336 IEA:EnsemblPdendritic cell migration
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0090136 IEA:EnsemblPepithelial cell-cell adhesion
GO:0060684 IEA:EnsemblPepithelial-mesenchymal cell signaling
GO:0051683 ISS:BHF-UCLPestablishment of Golgi localization
GO:0035088 IEA:EnsemblPestablishment or maintenance of apical/basal cell polarity
GO:0007163 TAS:UniProtKBPestablishment or maintenance of cell polarity
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0046847 IEA:EnsemblPfilopodium assembly
GO:0007030 ISS:BHF-UCLPGolgi organization
GO:0006184 TAS:GOCPGTP catabolic process
GO:0031069 IEA:EnsemblPhair follicle morphogenesis
GO:0060789 IEA:EnsemblPhair follicle placode formation
GO:0060047 IEA:EnsemblPheart contraction
GO:0045087 TAS:ReactomePinnate immune response
GO:0031424 IEA:EnsemblPkeratinization
GO:0003334 IEA:EnsemblPkeratinocyte development
GO:0030225 TAS:UniProtKBPmacrophage differentiation
GO:0035264 IEA:EnsemblPmulticellular organism growth
GO:0042692 TAS:ReactomePmuscle cell differentiation
GO:0042059 TAS:ReactomePnegative regulation of epidermal growth factor receptor signaling pathway
GO:0010629 IEA:EnsemblPnegative regulation of gene expression
GO:0031333 IPI:UniProtKBPnegative regulation of protein complex assembly
GO:0048664 IEA:EnsemblPneuron fate determination
GO:0007097 IEA:EnsemblPnuclear migration
GO:0072384 ISS:BHF-UCLPorganelle transport along microtubule
GO:0032467 IMP:UniProtKBPpositive regulation of cytokinesis
GO:0045740 IEA:EnsemblPpositive regulation of DNA replication
GO:0010628 IEA:EnsemblPpositive regulation of gene expression
GO:0071338 IEA:EnsemblPpositive regulation of hair follicle cell proliferation
GO:0090316 IEA:EnsemblPpositive regulation of intracellular protein transport
GO:0046330 IEA:EnsemblPpositive regulation of JNK cascade
GO:0048554 IEA:EnsemblPpositive regulation of metalloenzyme activity
GO:0051149 TAS:ReactomePpositive regulation of muscle cell differentiation
GO:0043525 IEA:EnsemblPpositive regulation of neuron apoptotic process
GO:0033138 IEA:EnsemblPpositive regulation of peptidyl-serine phosphorylation
GO:0043552 IEA:EnsemblPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0031274 IDA:UniProtKBPpositive regulation of pseudopodium assembly
GO:1900026 IDA:UniProtKBPpositive regulation of substrate adhesion-dependent cell spreading
GO:0051835 IEA:EnsemblPpositive regulation of synapse structural plasticity
GO:0051988 IMP:UniProtKBPregulation of attachment of spindle microtubules to kinetochore
GO:0051489 IDA:UniProtKBPregulation of filopodium assembly
GO:0007088 IEA:EnsemblPregulation of mitosis
GO:0042176 IEA:EnsemblPregulation of protein catabolic process
GO:0043497 IEA:EnsemblPregulation of protein heterodimerization activity
GO:0045859 IEA:EnsemblPregulation of protein kinase activity
GO:0031647 IEA:EnsemblPregulation of protein stability
GO:0051056 TAS:ReactomePregulation of small GTPase mediated signal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0002040 IEA:EnsemblPsprouting angiogenesis
GO:0060661 IEA:EnsemblPsubmandibular salivary gland formation
GO:0021762 IEP:UniProtKBPsubstantia nigra development
GO:0031295 TAS:ReactomePT cell costimulation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_18266Axon guidance
REACT_19183CD28 co-stimulation
REACT_19238CD28 dependent Vav1 pathway
REACT_21402CDO in myogenesis
REACT_19344Costimulation by the CD28 family
REACT_22351DCC mediated attractive signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_12484EGFR downregulation
REACT_263952EPHB-mediated forward signaling
REACT_264068EPH-Ephrin signaling
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_18407G alpha (12/13) signalling events
REACT_19184GPCR downstream signaling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_6900Immune System
REACT_19342Inactivation of Cdc42 and Rac
REACT_6802Innate Immune System
REACT_21303Myogenesis
REACT_22237Netrin-1 signaling
REACT_798Platelet activation, signaling and aggregation
REACT_160086Regulation of actin dynamics for phagocytic cup formation
REACT_11051Rho GTPase cycle
REACT_19277Sema4D induced cell migration and growth-cone collapse
REACT_19259Sema4D in semaphorin signaling
REACT_19271Semaphorin interactions
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_14797Signaling by GPCR
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_11044Signaling by Rho GTPases
REACT_19351Signaling by Robo receptor
REACT_12529Signaling by VEGF
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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