MGP Database

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MGP000488

UniProt Annotations

Entry Information
Gene Namecell division cycle 42
Protein Entry
UniProt IDP60953
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=2; Synonyms=Placental; IsoId=P60953-2, P21181-4; Sequence=Displayed; Name=1; Synonyms=Brain; IsoId=P60953-1, P21181-1; Sequence=VSP_040583, VSP_040584;
Enzyme RegulationRegulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
FunctionPlasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:17038317}.
InteractionSelf; NbExp=2; IntAct=EBI-81752, EBI-81752; O95477:ABCA1; NbExp=2; IntAct=EBI-81752, EBI-784112; Q07960:ARHGAP1; NbExp=2; IntAct=EBI-287394, EBI-602762; Q9UQB8:BAIAP2; NbExp=2; IntAct=EBI-287394, EBI-525456; Q9UQB8-4:BAIAP2; NbExp=4; IntAct=EBI-81752, EBI-6174091; Q9VEX9:Bin1 (xeno); NbExp=2; IntAct=EBI-81752, EBI-129424; Q5VT25:CDC42BPA; NbExp=5; IntAct=EBI-81752, EBI-689171; Q00587:CDC42EP1; NbExp=3; IntAct=EBI-81752, EBI-744130; P46940:IQGAP1; NbExp=2; IntAct=EBI-81752, EBI-297509; Q15811:ITSN1; NbExp=2; IntAct=EBI-3625591, EBI-602041; Q5S007:LRRK2; NbExp=3; IntAct=EBI-81752, EBI-5323863; Q16584:MAP3K11; NbExp=3; IntAct=EBI-81752, EBI-49961; Q96L34:MARK4; NbExp=2; IntAct=EBI-81752, EBI-302319; Q64096:Mcf2l (xeno); NbExp=3; IntAct=EBI-287394, EBI-602123; Q13153:PAK1; NbExp=7; IntAct=EBI-81752, EBI-1307; O75914:PAK3; NbExp=2; IntAct=EBI-287394, EBI-3389553; Q61036:Pak3 (xeno); NbExp=3; IntAct=EBI-81752, EBI-457317; O96013:PAK4; NbExp=2; IntAct=EBI-81752, EBI-713738; Q9NPB6:PARD6A; NbExp=7; IntAct=EBI-81752, EBI-81876; Q9BYG5:PARD6B; NbExp=7; IntAct=EBI-81752, EBI-295391; Q9JK83:Pard6b (xeno); NbExp=6; IntAct=EBI-81752, EBI-81861; Q9BYG4:PARD6G; NbExp=5; IntAct=EBI-81752, EBI-295417; P41743:PRKCI; NbExp=5; IntAct=EBI-81752, EBI-286199; O52623:sopE (xeno); NbExp=2; IntAct=EBI-81752, EBI-602254; Q07912:TNK2; NbExp=2; IntAct=EBI-287394, EBI-603457; P42768:WAS; NbExp=10; IntAct=EBI-81752, EBI-346375; O00401:WASL; NbExp=3; IntAct=EBI-81752, EBI-957615; O08816:Wasl (xeno); NbExp=2; IntAct=EBI-81752, EBI-6142604;
PtmAMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo. {ECO:0000269|PubMed:19039103, ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875}.
PtmPhosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor RhoGDI. {ECO:0000269|PubMed:14506284}.
SimilarityBelongs to the small GTPase superfamily. Rho family. CDC42 subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome.
SubunitThe GTP-bound form interacts with CCPG1 (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with activated CSPG4 and with BAIAP2. Interacts with Zizimin1/DOCK9 and Zizimin2/DOCK11, which activate it by exchanging GDP for GTP. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with USP6. May interact with ARHGEF16; responsible for the activation of CDC42 by the viral protein HPV16 E6. Interacts with NEK6. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with ITGB1BP1. Interacts with ARHGDIA; this interaction inactivates and stabilizes CDC42. {ECO:0000250, ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:10587647, ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11260256, ECO:0000269|PubMed:11807099, ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:12612085, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:19745154, ECO:0000269|PubMed:20622875, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21139582, ECO:0000269|PubMed:23434736}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CDC42ID40012ch1p36.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc42/";
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