MGP Database

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MGP000515

Ontology/Pathway Information

Entrez Gene ID1030
Gene Namecyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Gene Symbol CDKN2B
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IDA:UniProtKBCnucleus
GO:0004861 NAS:UniProtKBFcyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0019901 IPI:BHF-UCLFprotein kinase binding
GO:0007568 IEA:EnsemblPaging
GO:0007050 IMP:BHF-UCLPcell cycle arrest
GO:0031668 IMP:BHF-UCLPcellular response to extracellular stimulus
GO:0031670 IMP:BHF-UCLPcellular response to nutrient
GO:0000086 IMP:BHF-UCLPG2/M transition of mitotic cell cycle
GO:0010467 TAS:ReactomePgene expression
GO:0001889 IEA:EnsemblPliver development
GO:0030219 IEP:UniProtKBPmegakaryocyte differentiation
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0007093 IMP:BHF-UCLPmitotic cell cycle checkpoint
GO:0008285 IMP:BHF-UCLPnegative regulation of cell proliferation
GO:0050680 IMP:BHF-UCLPnegative regulation of epithelial cell proliferation
GO:2000134 IEA:EnsemblPnegative regulation of G1/S transition of mitotic cell cycle
GO:0042326 IDA:BHF-UCLPnegative regulation of phosphorylation
GO:0071901 IDA:GOCPnegative regulation of protein serine/threonine kinase activity
GO:0030858 IEA:EnsemblPpositive regulation of epithelial cell differentiation
GO:0045944 TAS:ReactomePpositive regulation of transcription from RNA polymerase II promoter
GO:0030511 IMP:BHF-UCLPpositive regulation of transforming growth factor beta receptor signaling pathway
GO:0000079 IDA:BHF-UCLPregulation of cyclin-dependent protein serine/threonine kinase activity
GO:0034097 IEA:EnsemblPresponse to cytokine
GO:0014070 IEA:EnsemblPresponse to organic cyclic compound
GO:0048536 IEA:EnsemblPspleen development
GO:0006351 TAS:ReactomePtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_821Cyclin D associated events in G1
REACT_116125Disease
REACT_1590G1 Phase
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_21267Mitotic G1-G1/S phases
REACT_169325Oncogene Induced Senescence
REACT_169436Oxidative Stress Induced Senescence
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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