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MGP000515

UniProt Annotations

Entry Information
Gene Namecyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Protein EntryCDN2B_HUMAN
UniProt IDP42772
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=p15; IsoId=P42772-1; Sequence=Displayed; Name=2; Synonyms=p10; IsoId=P42772-2; Sequence=VSP_043898;
FunctionInteracts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
InteractionP11802:CDK4; NbExp=8; IntAct=EBI-711280, EBI-295644; Q00534:CDK6; NbExp=3; IntAct=EBI-711280, EBI-295663;
SimilarityBelongs to the CDKN2 cyclin-dependent kinase inhibitor family. {ECO:0000305}.
SimilarityContains 4 ANK repeats. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:9230210}. Note=Also found in the nucleus.
SubunitHeterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6.
Tissue SpecificityIsoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. {ECO:0000269|PubMed:9230210}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CDKN2BID187ch9p21.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdkn2b/";
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