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MGP000516

UniProt Annotations

Entry Information
Gene Namecyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
Protein EntryCDN2C_HUMAN
UniProt IDP42773
SpeciesHuman
Comments
Comment typeDescription
FunctionInteracts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
InteractionP11802:CDK4; NbExp=3; IntAct=EBI-711290, EBI-295644; Q00534:CDK6; NbExp=3; IntAct=EBI-711290, EBI-295663;
SimilarityBelongs to the CDKN2 cyclin-dependent kinase inhibitor family. {ECO:0000305}.
SimilarityContains 4 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
SubunitHeterodimer of p18 with CDK6.
Tissue SpecificityHighest levels found in skeletal muscle. Also found in pancreas and heart.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdkn2c/";
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