MGP Database

MGP000557

Record overview

MGPD ID	MGP000557
Gene ID	1138
Species	Homo sapiens (Human)
Gene Name	cholinergic receptor, nicotinic, alpha 5 (neuronal)
Gene Symbol	CHRNA5
Synonyms	LNCR2;
Alternate names	neuronal acetylcholine receptor subunit alpha-5; acetylcholine receptor, nicotinic, alpha 5 (neuronal); neuronal nicotinic acetylcholine receptor, alpha5 subunit; Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5;
Chromosome	15
Map Location	15q24
Summary	The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]
Orthologs	View orthologs and multiple alignments for CHRNA5

Proteins

neuronal acetylcholine receptor subunit alpha-5 precursor

Refseq ID:	NP_000736
Protein GI:	33589827
UniProt ID:	P30532
mRNA ID:	NM_000745
Length:	468
RefSeq Status:

MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLK
QEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDI
ILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIE
EIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSI
RYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2263
peptide sequence: 
MAARGSGPRALRLLLLVQLVAG

mat_peptide: 23..468
product: Neuronal acetylcholine receptor subunit alpha-5
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P30532.2)
calculated_mol_wt: 50810
peptide sequence: 
RCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIR
VPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVS
ATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMI
FVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKF
IAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK