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MGP000557

UniProt Annotations

Entry Information
Gene Namecholinergic receptor, nicotinic, alpha 5 (neuronal)
Protein EntryACHA5_HUMAN
UniProt IDP30532
SpeciesHuman
Comments
Comment typeDescription
FunctionAfter binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
PolymorphismGenetic variations in CHRNA5 have been associated with susceptibility to smoking-related behavioral traits and lung cancer, contributing to the smoking quantitative trait locus 3 (SQTL3) [MIM:612052].
SimilarityBelongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 5/CHRNA5 sub-subfamily. {ECO:0000305}.
Subcellular LocationCell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
SubunitNeuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta).
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