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MGP000602

Record overview

MGPD IDMGP000602
Gene ID1236
SpeciesHomo sapiens (Human)
Gene Namechemokine (C-C motif) receptor 7
Gene Symbol CCR7
SynonymsBLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7;
Alternate namesC-C chemokine receptor type 7; MIP-3 beta receptor; CC chemokine receptor 7; Bukitt's lymphoma receptor 2; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; lymphocyte-specific G protein-coupled peptide receptor; Epstein-Barr virus-induced G-protein coupled receptor 1;
Chromosome17
Map Location17q12-q21.2
SummaryThe protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
OrthologsView orthologs and multiple alignments for CCR7

Proteins

C-C chemokine receptor type 7 isoform a precursor
Refseq ID:NP_001829
Protein GI:4502641
UniProt ID:P32248
mRNA ID:NM_001838
Length:378
RefSeq Status:
MDLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNL
AVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQ
RSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCEL
SKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRHIRRSSMSVEAETTTTFSP
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2620
peptide sequence: 
MDLGKPMKSVLVVALLVIFQVCLC
 
C-C chemokine receptor type 7 isoform b
Refseq ID:NP_001288643
Protein GI:683523912
UniProt ID:P32248
mRNA ID:NM_001301714
Length:315
RefSeq Status:
MYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVS
AHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIK
VIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRHIRR
SSMSVEAETTTTFSP
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2620
peptide sequence: 
MDLGKPMKSVLVVALLVIFQVCLC
 
C-C chemokine receptor type 7 isoform c precursor
Refseq ID:NP_001288645
Protein GI:683523916
UniProt ID:P32248
mRNA ID:NM_001301716
Length:372
RefSeq Status:
MKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADIL
FLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQ
AMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNI
AYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRHIRRSSMSVEAETTTTFSP
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2620
peptide sequence: 
MDLGKPMKSVLVVALLVIFQVCLC

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1979
peptide sequence: 
MKSVLVVALLVIFQVCLC

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1979
peptide sequence: 
MKSVLVVALLVIFQVCLC

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1979
peptide sequence: 
MKSVLVVALLVIFQVCLC
 
C-C chemokine receptor type 7 isoform c precursor
Refseq ID:NP_001288646
Protein GI:683523918
UniProt ID:P32248
mRNA ID:NM_001301717
Length:372
RefSeq Status:
Protein sequence is identical to GI:683523916 (mRNA isoform)
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2620
peptide sequence: 
MDLGKPMKSVLVVALLVIFQVCLC

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1979
peptide sequence: 
MKSVLVVALLVIFQVCLC
 
C-C chemokine receptor type 7 isoform c precursor
Refseq ID:NP_001288647
Protein GI:683523920
UniProt ID:P32248
mRNA ID:NM_001301718
Length:372
RefSeq Status:
Protein sequence is identical to GI:683523916 (mRNA isoform)
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2620
peptide sequence: 
MDLGKPMKSVLVVALLVIFQVCLC

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1979
peptide sequence: 
MKSVLVVALLVIFQVCLC

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1979
peptide sequence: 
MKSVLVVALLVIFQVCLC
 
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