MGP Database

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MGP000602

Ontology/Pathway Information

Entrez Gene ID1236
Gene Namechemokine (C-C motif) receptor 7
Gene Symbol CCR7
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:UniProtKBCcell surface
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0005622 IDA:BHF-UCLCintracellular
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0016493 ISS:BHF-UCLFC-C chemokine receptor activity
GO:0038117 IDA:UniProtKBFC-C motif chemokine 19 receptor activity
GO:0038121 IDA:UniProtKBFC-C motif chemokine 21 receptor activity
GO:0035757 IPI:BHF-UCLFchemokine (C-C motif) ligand 19 binding
GO:0035758 IPI:BHF-UCLFchemokine (C-C motif) ligand 21 binding
GO:0004930 TAS:BHF-UCLFG-protein coupled receptor activity
GO:0032862 IC:BHF-UCLPactivation of Rho GTPase activity
GO:0071345 IDA:BHF-UCLPcellular response to cytokine stimulus
GO:0038115 IDA:GOCPchemokine (C-C motif) ligand 19 signaling pathway
GO:0038116 IDA:GOCPchemokine (C-C motif) ligand 21 signaling pathway
GO:0070098 ISS:GOCPchemokine-mediated signaling pathway
GO:0002407 IC:BHF-UCLPdendritic cell chemotaxis
GO:0001768 IC:BHF-UCLPestablishment of T cell polarity
GO:0007186 TAS:BHF-UCLPG-protein coupled receptor signaling pathway
GO:0006955 IEA:EnsemblPimmune response
GO:0006954 NAS:BHF-UCLPinflammatory response
GO:0072610 ISS:BHF-UCLPinterleukin-12 secretion
GO:0097022 TAS:BHF-UCLPlymphocyte migration into lymph node
GO:0097029 ISS:BHF-UCLPmature dendritic cell differentiation
GO:0002408 IDA:BHF-UCLPmyeloid dendritic cell chemotaxis
GO:2000107 IC:BHF-UCLPnegative regulation of leukocyte apoptotic process
GO:0045060 IEA:EnsemblPnegative thymic T cell selection
GO:0030838 IC:BHF-UCLPpositive regulation of actin filament polymerization
GO:0045785 IC:BHF-UCLPpositive regulation of cell adhesion
GO:0001954 IC:BHF-UCLPpositive regulation of cell-matrix adhesion
GO:2000147 IC:BHF-UCLPpositive regulation of cell motility
GO:0007204 TAS:ProtIncPpositive regulation of cytosolic calcium ion concentration
GO:0002606 ISS:BHF-UCLPpositive regulation of dendritic cell antigen processing and presentation
GO:2000510 ISS:BHF-UCLPpositive regulation of dendritic cell chemotaxis
GO:0070374 IC:BHF-UCLPpositive regulation of ERK1 and ERK2 cascade
GO:0051491 IC:BHF-UCLPpositive regulation of filopodium assembly
GO:2000526 ISS:BHF-UCLPpositive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
GO:0002922 ISS:BHF-UCLPpositive regulation of humoral immune response
GO:0002885 ISS:BHF-UCLPpositive regulation of hypersensitivity
GO:0043123 IC:BHF-UCLPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:2000522 ISS:BHF-UCLPpositive regulation of immunological synapse formation
GO:0032735 ISS:BHF-UCLPpositive regulation of interleukin-12 production
GO:0046330 IC:BHF-UCLPpositive regulation of JNK cascade
GO:0090023 IDA:BHF-UCLPpositive regulation of neutrophil chemotaxis
GO:0043552 IC:BHF-UCLPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0045860 IC:BHF-UCLPpositive regulation of protein kinase activity
GO:0051897 IC:BHF-UCLPpositive regulation of protein kinase B signaling
GO:0031274 IC:BHF-UCLPpositive regulation of pseudopodium assembly
GO:2000525 ISS:BHF-UCLPpositive regulation of T cell costimulation
GO:0050862 IEA:EnsemblPpositive regulation of T cell receptor signaling pathway
GO:2000547 ISS:BHF-UCLPregulation of dendritic cell dendrite assembly
GO:0032649 ISS:BHF-UCLPregulation of interferon-gamma production
GO:0050706 ISS:BHF-UCLPregulation of interleukin-1 beta secretion
GO:0051209 IC:BHF-UCLPrelease of sequestered calcium ion into cytosol
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
GO:0071731 IC:BHF-UCLPresponse to nitric oxide
GO:0034695 IC:BHF-UCLPresponse to prostaglandin E
GO:0031529 IC:BHF-UCLPruffle organization
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_15344Chemokine receptors bind chemokines
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_19231G alpha (i) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14819Peptide ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
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